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Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications
其他题名Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications
LIAO RIJING; DUAN LIAN; LEI CHUN; PAN HAIXUE; DING YING; Zhang Q(张琪); CHEN DAIJIE; SHEN BEN; Yu Y(虞沂); Liu W(刘文)
2009
发表期刊Chem. Biol.
ISSN1074-5521
卷号16期号:2页码:141-147
摘要Thiopeptides, with potent activity against various drug-resistant pathogens, contain a characteristic macrocyclic core consisting of multiple thiazoles, dehydroamino acids, and a 6-membered nitrogen heterocycle. Their biosynthetic pathways remain elusive, in spite of great efforts by in vivo feeding experiments. Here, cloning, sequencing, and characterization of the thiostrepton and siomycin A gene clusters unveiled a biosynthetic paradigm for the thiopeptide specific core formation, featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. The paradigm generality for thiopeptide biosynthesis was supported by genome mining and ultimate confirmation of the thiocillin I production in Bacillus cereus ATCC 14579, a strain that was previously unknown as a thiopeptide producer. These findings set the stage to accelerate the discovery of thiopeptides by prediction at the genetic level and to generate structural diversity by applying combinatorial biosynthesis methods.
学科领域生命有机化学
部门归属上海有机所; 上海医药工业研究院; 上海交通大学; 美国威斯康星大学
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收录类别SCI
语种英语
WOS记录号WOS:000263852700006
引用统计
被引频次:113[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28453
专题生命有机化学国家重点实验室
通讯作者Yu Y(虞沂); Liu W(刘文)
推荐引用方式
GB/T 7714
LIAO RIJING,DUAN LIAN,LEI CHUN,et al. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications[J]. Chem. Biol.,2009,16(2):141-147.
APA LIAO RIJING.,DUAN LIAN.,LEI CHUN.,PAN HAIXUE.,DING YING.,...&刘文.(2009).Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications.Chem. Biol.,16(2),141-147.
MLA LIAO RIJING,et al."Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications".Chem. Biol. 16.2(2009):141-147.
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