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学科主题: 生命有机化学
题名: Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications
其他题名: Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications
作者: LIAO RIJING ; DUAN LIAN ; LEI CHUN ; PAN HAIXUE ; DING YING ; Zhang Q(张琪) ; CHEN DAIJIE ; SHEN BEN ; Yu Y(虞沂) ; Liu W(刘文)
通讯作者: 虞沂 ; 刘文
刊名: Chem. Biol.
发表日期: 2009-01-01
卷: 16, 期:2, 页:141-147
收录类别: SCI
部门归属: 上海有机所; 上海医药工业研究院; 上海交通大学; 美国威斯康星大学
英文摘要: Thiopeptides, with potent activity against various drug-resistant pathogens, contain a characteristic macrocyclic core consisting of multiple thiazoles, dehydroamino acids, and a 6-membered nitrogen heterocycle. Their biosynthetic pathways remain elusive, in spite of great efforts by in vivo feeding experiments. Here, cloning, sequencing, and characterization of the thiostrepton and siomycin A gene clusters unveiled a biosynthetic paradigm for the thiopeptide specific core formation, featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. The paradigm generality for thiopeptide biosynthesis was supported by genome mining and ultimate confirmation of the thiocillin I production in Bacillus cereus ATCC 14579, a strain that was previously unknown as a thiopeptide producer. These findings set the stage to accelerate the discovery of thiopeptides by prediction at the genetic level and to generate structural diversity by applying combinatorial biosynthesis methods.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000263852700006
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28453
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
LIAO RIJING,DUAN LIAN,LEI CHUN,et al. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications[J]. Chem. Biol.,2009,16(2):141-147.
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