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学科主题: 氟化学
题名: Tuning the Reactivity of Difluoromethyl Sulfoximines from Electrophilic to Nucleophilic: Stereoselective Nucleophilic Difluoromethylation of Aryl Ketones
其他题名: 调整二氟甲基亚砜亚胺的反应活性从亲电性到亲核性: 芳酮的立体选择性亲核二氟甲基化
作者: Shen X(沈晓) ; Zhang W(张伟) ; Ni CF(倪传法) ; Gu YC(顾玉诚) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: J. Am. Chem. Soc.
发表日期: 2012
卷: 134, 期:41, 页:16999-17002
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 先正达集团Jealotts Hill研究中心
英文摘要: A stereoselective synthesis of enantiomerically enriched difluoromethyl tertiary alcohols by tuning the reactivity of difluoromethyl sulfoximines from electrophilic to nucleophilic difluoromethylating agents is reported. The key feature of this chemistry is the diastereoselective addition of the difluoromethyl sulfoximine to the prochiral carbon of the ketone. The present method was used to prepare enantiomerically enriched difluoromethyl secondary alcohols and difluorinated analogues of the natural products gossonorol and boivinian B, demonstrating the potency of the method.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000309854700021
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28335
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Shen X,Zhang W,Ni CF,et al. Tuning the Reactivity of Difluoromethyl Sulfoximines from Electrophilic to Nucleophilic: Stereoselective Nucleophilic Difluoromethylation of Aryl Ketones[J]. J. Am. Chem. Soc.,2012,134(41):16999-17002.
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