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学科主题: 氟化学
题名: Copper-Mediated Trifluoromethylation of alpha-Diazo Esters with TMSCF3: The Important Role of Water as a Promoter
其他题名: 铜参与下利用TMSCF3试剂对α-重氮甲酸酯的三氟甲基化反应: 水作为重要的反应促进剂
作者: Hu MY(胡明友) ; Ni CF(倪传法) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: J. Am. Chem. Soc.
发表日期: 2012
卷: 134, 期:37, 页:15257-15260
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Copper-mediated trifluoromethylation of alpha-diazo esters with TMSCF3 reagent has been developed as a new method to prepare alpha-trifluoromethyl esters. This trifluoromethylation reaction represents the first example of fluoroalkylation of a non-fluorinated carbene precursor. Water plays an important role in promoting the reaction by activating the "CuCF3" species prepared from Cull TMSCF3/CsF (1.0:1.1:1.1). The scope of this trifluoromethylation reaction is broad, and its efficiency is demonstrated in the synthesis of a variety of aryl-, benzyl-, and alkyl-substituted 3,3,3-trifluoropropanoates.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000308830600024
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28331
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Hu MY,Ni CF,Hu JB. Copper-Mediated Trifluoromethylation of alpha-Diazo Esters with TMSCF3: The Important Role of Water as a Promoter[J]. J. Am. Chem. Soc.,2012,134(37):15257-15260.
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