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学科主题: 氟化学
题名: Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system
其他题名: 经由亚磺化脱卤的氟烷基化反应进展
作者: Zhang CP(张成潘) ; Chen QY(陈庆云) ; Guo Y(郭勇) ; Xiao JC(肖吉昌) ; Gu YC(顾玉诚)
通讯作者: 郭勇 ; 肖吉昌
刊名: Chem. Soc. Rev.
发表日期: 2012
卷: 41, 期:12, 页:4536-4559
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 先正达
英文摘要: The sulfinatodehalogenation reaction represents one of the most important methodologies to incorporate fluorine into organic molecules. Using inexpensive sulfur-containing reactants such as Na2S2O4 under mild conditions, per-and polyfluoroalkyl halides (RFX, X = Br, I, CCl3) can be transformed smoothly into the corresponding sulfinate salts. This method is also used for the perfluoroalkylation of alkenes, dienes, alkynes and aromatics. Notably, after 1998, the sulfinatodehalogenation of perfluoroalkyl chlorides (RFCl) has been realized by using dimethylsulfoxide (DMSO) as a solvent instead of CH3CN/H2O in the Na2S2O4/NaHCO3 initiation system. Perfluoroalkyl chlorides, ethyl chlorofluoroacetates and chlorodifluoroacetates, and even nonfluorinated compounds, such as ethyl chloro-or dichloroacetates and chloroform, were either converted into the corresponding sulfinate salts or alkylated alkenes, alkynes and aromatics (including porphyrins). The sulfinatodehalogenation reaction has remarkable advantages. With the increasing demands to utilize the unique properties of fluorine and fluorinated functional groups in medicinal, agricultural and material sciences, we believe that there will continue to be useful developments in sulfinatodehalogenation chemistry and it will be applied more widely in the future.
语种: 英语
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WOS记录号: WOS:000304555700009
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28293
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Zhang CP,Chen QY,Guo Y,et al. Progress in fluoroalkylation of organic compounds via sulfinatodehalogenation initiation system[J]. Chem. Soc. Rev.,2012,41(12):4536-4559.
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