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学科主题: 氟化学
题名: Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes
其他题名: 铜催化杂环芳烃C-H键的直接氧化三氟甲基化反应
作者: Chu LL(储玲玲) ; Qing FL(卿凤翎)
通讯作者: 卿凤翎
刊名: J. Am. Chem. Soc.
发表日期: 2012-01-01
卷: 134, 期:2, 页:1298-1304
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 东华大学
英文摘要: This article describes the copper-catalyzed oxidative trifluoromethylation of heteroarenes and highly electron-deficient arenes with CF3SiMe3 through direct C-H activation. In the presence of catalyst Cu(OAc)(2), ligand 1,10-phenanthroline and cobases tert-BuONa/NaOAc, oxidative trifluoromethylation of 1,3,4-oxadiazoles with CF3SiMe3 proceeded smoothly using either air or di-tert-butyl peroxide as an oxidant to give the corresponding trifluoromethylated 1,3,4-oxadiazoles in high yields. Di-tert-butyl peroxide was chosen as the suitable oxidant for oxidative trifluoromethylation of 1,3-azoles and perfluoroarenes. Cu(OH)(2) and Ag2CO3 were the best catalyst and oxidant for direct oxidative trifluoromethyaltion of indoles. The optimum reaction conditions enable oxidative trifluoromethylation of a range of heteroarenes that bear numerous functional groups. The prepared trifluoromethylated heteroarenes are of importance in the areas of pharmaceuticals and agrochemicals. The preliminary mechanistic studies of these oxidative trifluoromethylations are also reported.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000301084300091
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28287
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Chu LL,Qing FL. Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes[J]. J. Am. Chem. Soc.,2012,134(2):1298-1304.
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