SIOC OpenIR  > 中科院有机氟化学重点实验室
Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes
其他题名铜催化杂环芳烃C-H键的直接氧化三氟甲基化反应
Chu LL(储玲玲); Qing FL(卿凤翎)
2012
发表期刊J. Am. Chem. Soc.
ISSN0002-7863
卷号134期号:2页码:1298-1304
摘要This article describes the copper-catalyzed oxidative trifluoromethylation of heteroarenes and highly electron-deficient arenes with CF3SiMe3 through direct C-H activation. In the presence of catalyst Cu(OAc)(2), ligand 1,10-phenanthroline and cobases tert-BuONa/NaOAc, oxidative trifluoromethylation of 1,3,4-oxadiazoles with CF3SiMe3 proceeded smoothly using either air or di-tert-butyl peroxide as an oxidant to give the corresponding trifluoromethylated 1,3,4-oxadiazoles in high yields. Di-tert-butyl peroxide was chosen as the suitable oxidant for oxidative trifluoromethylation of 1,3-azoles and perfluoroarenes. Cu(OH)(2) and Ag2CO3 were the best catalyst and oxidant for direct oxidative trifluoromethyaltion of indoles. The optimum reaction conditions enable oxidative trifluoromethylation of a range of heteroarenes that bear numerous functional groups. The prepared trifluoromethylated heteroarenes are of importance in the areas of pharmaceuticals and agrochemicals. The preliminary mechanistic studies of these oxidative trifluoromethylations are also reported.
学科领域氟化学
部门归属中科院上海有机化学研究所; 东华大学
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000301084300091
引用统计
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28287
专题中科院有机氟化学重点实验室
通讯作者Qing FL(卿凤翎)
推荐引用方式
GB/T 7714
Chu LL,Qing FL. Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes[J]. J. Am. Chem. Soc.,2012,134(2):1298-1304.
APA 储玲玲,&卿凤翎.(2012).Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes.J. Am. Chem. Soc.,134(2),1298-1304.
MLA 储玲玲,et al."Copper-Catalyzed Direct C-H Oxidative Trifluoromethylation of Heteroarenes".J. Am. Chem. Soc. 134.2(2012):1298-1304.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2012218.pdf(1419KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[储玲玲]的文章
[卿凤翎]的文章
百度学术
百度学术中相似的文章
[储玲玲]的文章
[卿凤翎]的文章
必应学术
必应学术中相似的文章
[储玲玲]的文章
[卿凤翎]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。