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学科主题: 氟化学
题名: A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates
其他题名: 亚胺酰卤中间体参与下的一锅法合成2-氟烷基1,3-咪唑啉或1,3-恶唑啉
作者: Jiang HZ(蒋海珍) ; Sun L(孙兰) ; Yuan SJ(袁世杰) ; Lu WJ(卢文君) ; Wan W(万文) ; Zhu SZ(朱仕正) ; Hao J(郝建)
通讯作者: 蒋海珍 ; 朱仕正 ; 郝建
刊名: Tetrahedron
发表日期: 2012
卷: 68, 期:13, 页:2858-2863
收录类别: SCI
部门归属: 上海大学; 中科院上海有机化学研究所
英文摘要: A facile one-pot procedure has been developed for the synthesis of 1,3-imidazolines and 1,3-oxazolines bearing fluorinated alkyl groups at the 2-position. The reaction involves the condensation of N-monosubstituted ethane-1,2-diamines or 2-aminoethanols with a fluorinated carboxylic acid in the presence of PPh3/CX4. The proposed mechanism is that the amide intermediates were initially formed, and then converted to the imidoyl halide intermediates in the presence of PPh3/CX4, followed by rapid intramolecular cyclization to 1,3-diazoline products. This protocol allows for the synthesis of 2-bromodifluoromethyl-1,3-imidazoline, a useful CF2Br-heterocyclic building block, which can be used for the synthesis of gem-difluoromethylene linked compounds. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000301964700014
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28267
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Jiang HZ,Sun L,Yuan SJ,et al. A facile one-pot synthesis of 2-fluoroalkyl 1,3-imidazolines and 1,3-oxazolines through imidoyl halide intermediates[J]. Tetrahedron,2012,68(13):2858-2863.
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