SIOC OpenIR  > 中科院有机氟化学重点实验室
Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs
Alternative TitleSGLT2抑制剂的合成和生物评价: gem-二氟亚甲基Dapagliflozin类似物
Chen ZH(陈增浩); Wang RW(王若文); Qing FL(卿凤翎)
2012
Source PublicationTetrahedron Lett.
ISSN0040-4039
Volume53Issue:17Pages:2171-2176
AbstractDapagliflozin is currently the most advanced SGLT2 inhibitor, which has been used in Phase III clinical trials for treatment of diabetes. Here we describe the design and synthesis of Dapagliflozin analogs modified with gem-difluoromethylene group. Their biological evaluation of in vitro inhibitory activity against human SGLT2 showed that some of the analogs with CF2 at C-4 are better SGLT2 inhibitors compared with Dapagliflozin. (c) 2012 Elsevier Ltd. All rights reserved.
Subject Area氟化学
Department中科院上海有机化学研究所; 东华大学
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000302587800007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/28249
Collection中科院有机氟化学重点实验室
Corresponding AuthorQing FL(卿凤翎)
Recommended Citation
GB/T 7714
Chen ZH,Wang RW,Qing FL. Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs[J]. Tetrahedron Lett.,2012,53(17):2171-2176.
APA 陈增浩,王若文,&卿凤翎.(2012).Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs.Tetrahedron Lett.,53(17),2171-2176.
MLA 陈增浩,et al."Synthesis and biological evaluation of SGLT2 inhibitors: gem-difluoromethylenated Dapagliflozin analogs".Tetrahedron Lett. 53.17(2012):2171-2176.
Files in This Item:
File Name/Size DocType Version Access License
2012116.pdf(1187KB) 开放获取--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[陈增浩]'s Articles
[王若文]'s Articles
[卿凤翎]'s Articles
Baidu academic
Similar articles in Baidu academic
[陈增浩]'s Articles
[王若文]'s Articles
[卿凤翎]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[陈增浩]'s Articles
[王若文]'s Articles
[卿凤翎]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.