中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 金属有机化学国家重点实验室  > 期刊论文
学科主题: 金属有机化学
题名: Nucleophilic Addition of Grignard Reagents to 3-Acylindoles: Stereoselective Synthesis of Highly Substituted Indoline Scaffolds
其他题名: 格氏试剂对3-酰基吲哚的亲核加成反应:立体选择性合成多取代吲哚啉衍生物
作者: Wang L(王璐) ; Shao YS(邵羽裳) ; Liu YH(刘元红)
通讯作者: 刘元红
刊名: Org. Lett.
发表日期: 2012
卷: 14, 期:15, 页:3978-3981
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 华东师范大学
英文摘要: 3-Acylindoles undergo nucleophilic-type reactions with Grignard reagents to efficiently afford either cis- or trans-substituted indolines, depending on the different quenching procedures. The enolate intermediate could be trapped by aryl acyl chlorides to provide indolines bearing a quaternary carbon center with high stereoselectivity. In contrast, the use of benzyl bromide as an electrophile results in the fragmentation of the indole ring. The indoline products could be easily transformed Into indoles through oxidation with DDQ in a one-pot manner.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000307041600043
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28107
Appears in Collections:金属有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2012401.pdf(344KB)----开放获取--View Download

Recommended Citation:
Wang L,Shao YS,Liu YH. Nucleophilic Addition of Grignard Reagents to 3-Acylindoles: Stereoselective Synthesis of Highly Substituted Indoline Scaffolds[J]. Org. Lett.,2012,14(15):3978-3981.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王璐]'s Articles
[邵羽裳]'s Articles
[刘元红]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王璐]‘s Articles
[邵羽裳]‘s Articles
[刘元红]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2012401.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace