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学科主题: 金属有机化学
题名: Asymmetric synthesis of beta-aryl-beta-trifluoromethyl-beta-aminoarones via Mannich-type reactions of ketone enolates with chiral aryl CF3-substituted N-tert-butanesulfinyl ketimines
其他题名: 酮烯醇与手性的CF 3-取代的N-叔butanesulfinyl酮亚胺的曼尼希反应不对称合成β-芳基-β-三氟甲基-β-aminoarones
作者: Liu YL(刘应乐) ; Huang YG(黄焰根) ; Qing FL(卿凤翎)
通讯作者: 黄焰根
刊名: Tetrahedron
发表日期: 2012
卷: 68, 期:25, 页:4955-4961
收录类别: SCI
部门归属: 东华大学; 中科院上海有机化学研究所
英文摘要: A method for the preparation of chiral beta-aryl-beta-trifluoromethyl-beta-aminoarones has been developed involving the Mannich-type reactions of ketone-derivative enolates with chiral aryl CF3-substituted N-tert-butanesulfinyl ketimines. This method tolerates a wide of aromatic ketones, giving the products in moderate to excellent yields (up to 91%) with good diastereoselectiveties (up to 93:7 dr). Acidic cleavage of the tert-butanesulfinyl group gave optically pure beta-aryl-beta-trifluoromethyl-beta-aminoarones in excellent yields (up to 98%), which can be further transformed into CF3-substituted aziridine derivatives. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000304892800003
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27963
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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Recommended Citation:
Liu YL,Huang YG,Qing FL. Asymmetric synthesis of beta-aryl-beta-trifluoromethyl-beta-aminoarones via Mannich-type reactions of ketone enolates with chiral aryl CF3-substituted N-tert-butanesulfinyl ketimines[J]. Tetrahedron,2012,68(25):4955-4961.
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