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学科主题: 生命有机化学
题名: Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
其他题名: Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
作者: Zhao QF(赵群飞) ; He QL(贺庆利) ; Ding W(丁伟) ; Tang MC(唐满成) ; Kang QJ(康前进) ; Yu Y(虞沂) ; Deng W(邓玮) ; Zhang Q(张琪) ; Fang J(方洁) ; Tang GL(唐功利) ; Liu W(刘文)
通讯作者: 刘文
刊名: Chem. Biol.
发表日期: 2008
卷: 15, 期:7, 页:693-705
收录类别: SCI
部门归属: 上海有机所; 兰州大学; 上海交通大学
英文摘要: Azinomycin B is a complex natural product containing densely assembled functionalities with potent antitumor activity. Cloning and sequence analysis of the azi gene cluster revealed an iterative type I polyketide synthase (PKS) gene, five nonribosomal peptide synthetases (NRPSs) genes and numerous genes encoding the biosynthesis of unusual building blocks and tailoring steps for azinomycin B production. Characterization of AziB as a 5-methyl-naphthoic acid (NP) synthase showed a distinct selective reduction pattern in aromatic polyketide biosynthesis governed by bacterial iterative type I PKSs. Heterologous expression established the PKS-post modification route from 5-methyl-NPA to reach the first building block 3-methoxy-5-methyl-NPA. This proposed azinomycin B biosynthetic pathway sets the stage to investigate the enzymatic mechanisms for building structurally unique and pharmaceutically important groups, including the unprecedented azabicyclic ring system and highly active epoxide moiety.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000258019700010
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27713
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zhao QF,He QL,Ding W,et al. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis[J]. Chem. Biol.,2008,15(7):693-705.
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