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Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
其他题名Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis
Zhao QF(赵群飞); He QL(贺庆利); Ding W(丁伟); Tang MC(唐满成); Kang QJ(康前进); Yu Y(虞沂); Deng W(邓玮); Zhang Q(张琪); Fang J(方洁); Tang GL(唐功利); Liu W(刘文)
2008
发表期刊Chem. Biol.
ISSN1074-5521
卷号15期号:7页码:693-705
摘要Azinomycin B is a complex natural product containing densely assembled functionalities with potent antitumor activity. Cloning and sequence analysis of the azi gene cluster revealed an iterative type I polyketide synthase (PKS) gene, five nonribosomal peptide synthetases (NRPSs) genes and numerous genes encoding the biosynthesis of unusual building blocks and tailoring steps for azinomycin B production. Characterization of AziB as a 5-methyl-naphthoic acid (NP) synthase showed a distinct selective reduction pattern in aromatic polyketide biosynthesis governed by bacterial iterative type I PKSs. Heterologous expression established the PKS-post modification route from 5-methyl-NPA to reach the first building block 3-methoxy-5-methyl-NPA. This proposed azinomycin B biosynthetic pathway sets the stage to investigate the enzymatic mechanisms for building structurally unique and pharmaceutically important groups, including the unprecedented azabicyclic ring system and highly active epoxide moiety.
学科领域生命有机化学
部门归属上海有机所; 兰州大学; 上海交通大学
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收录类别SCI
语种英语
WOS记录号WOS:000258019700010
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被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/27713
专题上海有机化学研究所
通讯作者Liu W(刘文)
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GB/T 7714
Zhao QF,He QL,Ding W,et al. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis[J]. Chem. Biol.,2008,15(7):693-705.
APA 赵群飞.,贺庆利.,丁伟.,唐满成.,康前进.,...&刘文.(2008).Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.Chem. Biol.,15(7),693-705.
MLA 赵群飞,et al."Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis".Chem. Biol. 15.7(2008):693-705.
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