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学科主题: 金属有机化学
题名: Stereoselective Synthesis of Multifunctionalized 1,2,4-Triazolidines by a Ruthenium Porphyrin-Catalyzed Three-Component Coupling Reaction
其他题名: 钌卟啉催化的三分子反应来合成1,2,4-三唑烷类化合物
作者: Wang MZ(汪明中) ; Xu HW(徐海伟) ; Liu YG(刘云亘) ; Huang WJ(黄文健) ; Zhi ZM(支志明)
通讯作者: 黄文健 ; 支志明
刊名: Adv. Synth. Catal.
发表日期: 2006-01-01
卷: 348, 期:16-17, 页:2391-2396
收录类别: SCI
部门归属: 香港大学; 上海有机所
英文摘要: Multifunctionalized 1,2,4-triazolidines have been synthesized by a ruthenium porphyrin-catalyzed three-component coupling reaction. In a one-pot reaction, ruthenium porphyrins catalyzed the in situ generation of azomethine ylides from alpha-diazo esters and imines. Stereoselective 1,3-dipolar cycloaddition reactions of the azomethine ylides with dialkyl azodicarboxylates gave the corresponding 1,2,4-triazolidines in good yields (up to 85 %). Using chiral 8-phenylmenthanol alpha-diazo-ester as the carbenoid source, chiral 1,2,4-triazolidines have been obtained with good diastereoselectivity (up to 84 % de). Some of the 1,2,4-triazolidines exhibited good cytotoxicity against human nasopharyngeal carcinoma (SUNE1) (IC50=10.4 mu m) and human cervical carcinoma (Hela) (IC50=10.7 mu m) cell lines.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27663
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Wang MZ,Xu HW,Liu YG,et al. Stereoselective Synthesis of Multifunctionalized 1,2,4-Triazolidines by a Ruthenium Porphyrin-Catalyzed Three-Component Coupling Reaction[J]. Adv. Synth. Catal.,2006,348(16-17):2391-2396.
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