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学科主题: 分析化学
题名: Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector dirriethyl diphenyl bicarboxylate
其他题名: Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector dirriethyl diphenyl bicarboxylate
作者: Gao WH(高文华) ; Kang JW(康经武)
通讯作者: 康经武
刊名: J. Chromatogr. A
发表日期: 2006-01-01T00:00:00Z
卷: 1108, 期:1, 页:145-148
收录类别: SCI
部门归属: 上海有机所; 兰州大学
英文摘要: Separation of atropisomers of analogues of the anti-hepatitis drug dimethyl diphenyl bicarboxyl ate (DDB) by capillary electrophoresis with vancomycin as the chiral selector is described. Among several tested chiral selectors, including various cyclodextrin derivatives as well as vancomycin, only the latter displayed the enantioselectivity to the studied atropisomers. However, relatively poor separation efficiency was obtained due to the adsorption of vancomycin oil the capillary wall. This problem was overcome by modifying the capillary wall with it polycationic electrolyte named hexadimethrine bromide (HDB) to produce 1 positively charged coating, which minimized the adsorption of vancomycin on the capillary wall by electrostatic repulsion. Moreover, the positively charged coating could shorten the separation time by reversing the EOF because the reversed EOF migrated to the same direction as the negatively charged analyte. Effects of buffer pH, vancomycin and buffer concentrations and applied voltage oil the separation were investigated and the optimal conditions were established as follows: 40 mM Tris-phosphate buffer (pH 6.0) containing 6.0 mM vancomycin and 0.001% HDB. Baseline separation of three racemic DDB analogues was obtained within 12 min under the optimal conditions. (c) 2006 Elsevier B.V. All rights reserved.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27649
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Gao WH,Kang JW. Separation of atropisomers of anti-hepatitis drug dimethyl diphenyl bicarboxylate analogues by capillary electrophoresis with vancomycin as the chiral selector dirriethyl diphenyl bicarboxylate[J]. J. Chromatogr. A,2006,1108(1):145-148.
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