SIOC OpenIR  > 上海有机化学研究所
An on-column derivatization method for the determination of the enantiomeric excess of chiral primary amines via indirect enantioseparation by micellar electrokinetic chromatography on-column derivatization
其他题名An on-column derivatization method for the determination of the enantiomeric excess of chiral primary amines via indirect enantioseparation by micellar electrokinetic chromatography on-column derivatization
Cheng JY(程佳懿); Kang JW(康经武)
2006
发表期刊Electrophoresis
ISSN0173-0835
卷号27期号:4页码:865-871
摘要A method used for determining the enantiomeric excess (ee) value of chiral amino compounds by MEKC is described. In this method, the plug-plug type electrophoretic medicated microanalysis technique was employed to convert the enantiomers of chiral amino compounds into their diastereomers through an on-column derivatization with o-phthaldialdehyde and the chiral reagent N-acetyl-L-cysteine. Afterwards, the resulting diastereomers were easily separated with a nonchiral MEKC approach. The on-column derivatization conditions and the separation conditions were optimized and the method was validated with five chiral amino compounds. The present method can be used for assaying the ee value of chiral amino compound with various structural features, especially for those that have no UV chromophore. Therefore, the method can be potentially used for screening or evaluation of the asymmetric catalysts developed by the combinatorial chemistry. In this case, the ee values of chiral products with various structures need to be measured; however, this is difficult for direct chiral separation approach due to the fact that the chiral selectivity is strongly dependent on the structure of the analytes. The method is simple, reliable, and automatic.
学科领域分析化学
部门归属上海有机所
URL查看原文
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/27647
专题上海有机化学研究所
通讯作者Kang JW(康经武)
推荐引用方式
GB/T 7714
Cheng JY,Kang JW. An on-column derivatization method for the determination of the enantiomeric excess of chiral primary amines via indirect enantioseparation by micellar electrokinetic chromatography on-column derivatization[J]. Electrophoresis,2006,27(4):865-871.
APA 程佳懿,&康经武.(2006).An on-column derivatization method for the determination of the enantiomeric excess of chiral primary amines via indirect enantioseparation by micellar electrokinetic chromatography on-column derivatization.Electrophoresis,27(4),865-871.
MLA 程佳懿,et al."An on-column derivatization method for the determination of the enantiomeric excess of chiral primary amines via indirect enantioseparation by micellar electrokinetic chromatography on-column derivatization".Electrophoresis 27.4(2006):865-871.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2006285.pdf(353KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[程佳懿]的文章
[康经武]的文章
百度学术
百度学术中相似的文章
[程佳懿]的文章
[康经武]的文章
必应学术
必应学术中相似的文章
[程佳懿]的文章
[康经武]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。