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学科主题: 生命有机化学
题名: Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis
其他题名: 克隆并鉴定一个来源于细菌的重复使用的I型聚酮合成酶基因编码6-甲基水扬酸合成酶
作者: Shao L(邵雷) ; Ju XD(瞿旭东) ; Jia XY(贾新颖) ; Zhao QF(赵群飞) ; Tian ZH(田振华) ; Wang M(王闵) ; Tang GL(唐功利) ; Liu W(刘文)
通讯作者: 唐功利 ; 刘文
刊名: Biochem. Biophys. Res. Commun.
发表日期: 2006-01-01
卷: 345, 期:1, 页:133-139
收录类别: SCI
部门归属: 中国药科大学; 中科院上海有机所
英文摘要: Unusual polyketide synthases (PKSs), that are structurally type I but act in an iterative manner for aromatic polyketide biosynthesis, are a new family found in bacteria. Here we report the cloning of the iterative type I PKS gene chlB1 from the chlorothricin (CHL) producer Streptomyces antibioticus DSM 40725 by a rapid PCR approach, and characterization of the function of the gene product as a 6-methylsalicyclic acid synthase (6-MSAS). Sequence analysis of various iterative type I PKSs suggests that the resulting aromatic or aliphatic structure of the products might be intrinsically determined by a catalytic feature of the paired KR-DH domains in the control of the double bond geometry. The finding of ChlB1 as a 6-MSAS not only enriches the current knowledge of aromatic polyketide biosynthesis in bacteria, but will also contribute to the generation of novel polyketide analogs via combinatorial biosynthesis with engineered PKSs. (c) 2006 Elsevier Inc. All rights reserved.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27641
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Shao L,Ju XD,Jia XY,et al. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis[J]. Biochem. Biophys. Res. Commun.,2006,345(1):133-139.
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