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Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis
其他题名克隆并鉴定一个来源于细菌的重复使用的I型聚酮合成酶基因编码6-甲基水扬酸合成酶
Shao L(邵雷); Ju XD(瞿旭东); Jia XY(贾新颖); Zhao QF(赵群飞); Tian ZH(田振华); Wang M(王闵); Tang GL(唐功利); Liu W(刘文)
2006
发表期刊Biochem. Biophys. Res. Commun.
ISSN0006-291X
卷号345期号:1页码:133-139
摘要Unusual polyketide synthases (PKSs), that are structurally type I but act in an iterative manner for aromatic polyketide biosynthesis, are a new family found in bacteria. Here we report the cloning of the iterative type I PKS gene chlB1 from the chlorothricin (CHL) producer Streptomyces antibioticus DSM 40725 by a rapid PCR approach, and characterization of the function of the gene product as a 6-methylsalicyclic acid synthase (6-MSAS). Sequence analysis of various iterative type I PKSs suggests that the resulting aromatic or aliphatic structure of the products might be intrinsically determined by a catalytic feature of the paired KR-DH domains in the control of the double bond geometry. The finding of ChlB1 as a 6-MSAS not only enriches the current knowledge of aromatic polyketide biosynthesis in bacteria, but will also contribute to the generation of novel polyketide analogs via combinatorial biosynthesis with engineered PKSs. (c) 2006 Elsevier Inc. All rights reserved.
学科领域生命有机化学
部门归属中国药科大学; 中科院上海有机所
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收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/27641
专题上海有机化学研究所
通讯作者Tang GL(唐功利); Liu W(刘文)
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GB/T 7714
Shao L,Ju XD,Jia XY,et al. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis[J]. Biochem. Biophys. Res. Commun.,2006,345(1):133-139.
APA 邵雷.,瞿旭东.,贾新颖.,赵群飞.,田振华.,...&刘文.(2006).Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis.Biochem. Biophys. Res. Commun.,345(1),133-139.
MLA 邵雷,et al."Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis".Biochem. Biophys. Res. Commun. 345.1(2006):133-139.
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