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Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis
Alternative Title遗传鉴定氯丝菌素生物合成基因簇作为螺4-羟基乙酰乙酸内酯类抗生素生物合成的模式
Jia XY(贾新颖); Tian ZH(田振华); Shao L(邵雷); Ju XD(瞿旭东); Zhao QF(赵群飞); Tang J(唐键); Tang GL(唐功利); Liu W(刘文)
2006
Source PublicationChem. Biol.
ISSN1074-5521
Volume13Issue:6Pages:575-585
AbstractThe biosynthetic gene cluster for chlorothricin (CHL) was localized to a 122 kb contiguous DNA from Streptomyces antibioticus DSM 40725, and its involvement in CHL biosynthesis was confirmed by gene inactivation and complementation. Bioinformatic analysis of the sequenced 111.989 kb DNA region revealed 42 open reading frames, 35 of which were defined to constitute the CHL gene cluster. An assembly model for CHL biosynthesis from D-olivose, 2-methoxy-5chloro-6-methylsalicyclic acid, and chlorothricolide building blocks was proposed. This work represents cloning of a gene cluster for spirotetronate antibiotic biosynthesis and sets the stage to investigate the unusual macrolide biosynthesis including tandem Diels-Alder cyclizations, Baeyer-Villiger oxidation, and incorporation of an enoylpyruvate unit.
Subject Area生命有机化学
Department中科院上海有机所; 中国药科大学
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Indexed BySCI
Language英语
WOS IDWOS:000238723800006
Citation statistics
Cited Times:104[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/27637
Collection上海有机化学研究所
Corresponding AuthorTang GL(唐功利); Liu W(刘文)
Recommended Citation
GB/T 7714
Jia XY,Tian ZH,Shao L,et al. Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis[J]. Chem. Biol.,2006,13(6):575-585.
APA 贾新颖.,田振华.,邵雷.,瞿旭东.,赵群飞.,...&刘文.(2006).Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.Chem. Biol.,13(6),575-585.
MLA 贾新颖,et al."Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis".Chem. Biol. 13.6(2006):575-585.
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