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学科主题: 生命有机化学
题名: Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis
其他题名: 遗传鉴定氯丝菌素生物合成基因簇作为螺4-羟基乙酰乙酸内酯类抗生素生物合成的模式
作者: Jia XY(贾新颖) ; Tian ZH(田振华) ; Shao L(邵雷) ; Ju XD(瞿旭东) ; Zhao QF(赵群飞) ; Tang J(唐键) ; Tang GL(唐功利) ; Liu W(刘文)
通讯作者: 唐功利 ; 刘文
刊名: Chem. Biol.
发表日期: 2006
卷: 13, 期:6, 页:575-585
收录类别: SCI
部门归属: 中科院上海有机所; 中国药科大学
英文摘要: The biosynthetic gene cluster for chlorothricin (CHL) was localized to a 122 kb contiguous DNA from Streptomyces antibioticus DSM 40725, and its involvement in CHL biosynthesis was confirmed by gene inactivation and complementation. Bioinformatic analysis of the sequenced 111.989 kb DNA region revealed 42 open reading frames, 35 of which were defined to constitute the CHL gene cluster. An assembly model for CHL biosynthesis from D-olivose, 2-methoxy-5chloro-6-methylsalicyclic acid, and chlorothricolide building blocks was proposed. This work represents cloning of a gene cluster for spirotetronate antibiotic biosynthesis and sets the stage to investigate the unusual macrolide biosynthesis including tandem Diels-Alder cyclizations, Baeyer-Villiger oxidation, and incorporation of an enoylpyruvate unit.
语种: 英语
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WOS记录号: WOS:000238723800006
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27637
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Jia XY,Tian ZH,Shao L,et al. Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis[J]. Chem. Biol.,2006,13(6):575-585.
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