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学科主题: 天然产物有机化学
题名: 光学活性(+)-3-甲氧基-7α-甲基-17α-氰甲基-17β-羟基-1,3,5(10)-雌甾三烯的合成
其他题名: THE SYNTHESIS OF (+)-3-METHOXY-7-ALPHA-METHYL-17-ALPHA-CYANOMETHYL-17-BETA-HYDROXY-1,3,5( 10)-ESTRATRIENE
作者: 蔡祖恽 ; 倪元 ; 张量
通讯作者: 蔡祖恽
刊名: 化学学报
发表日期: 1993-01-01
卷: 51, 期:6, 页:607-611
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 上海市华东化工学院
英文摘要: The titled compound 12 was obtained through seven steps using the compound 3 as starting material. Hydrogenated compound 4 obtained from 8 was cyclized with H2SO4 to the compound 6, hydrogenation of which gave a mixture of the compound 7 and 8. The compound 8 was also secured directly by reduction of 6 with Li and liq. NH3. Deprotection of the compound 8 by HCl gave the compound 9 which was oxidized to the compound 10. Introducing the methylene group by dimethyl oxosulfonium methylide at 17-ketone in the compound 10 gave the epoxide 11 which was cleavaged to the titled compound 12 by NaCN.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/27307
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
蔡祖恽,倪元,张量. 光学活性(+)-3-甲氧基-7α-甲基-17α-氰甲基-17β-羟基-1,3,5(10)-雌甾三烯的合成[J]. 化学学报,1993,51(6):607-611.
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