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学科主题: 天然产物有机化学 ; 氟化学
题名: Synthesis and properties of trifluoromethylating steroid compounds
其他题名: Synthesis and properties of trifluoromethylating steroid compounds
作者: Wang ZQ(王钟麒) ; Lu SF(卢寿福) ; Zhang JR(张建蓉)
通讯作者: 王钟麒
刊名: Sci. China Ser. B-Chem.
发表日期: 1997-01-01
卷: 40, 期:3, 页:294-301
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: Trifluoromethyl steroids 1a, b; 2a, b; 3a, b have been synthesized by starring from Delta(5(10))-estren-3, 17-dicarbonyl-3, 3-dimethyl ether (4) and dl-18-methyl-Delta(2(3),5(10))-estra-diene-17-carbonyl-3-methyl ether (5), and by using trimthyltrifluoromethylsilane as the trifluoromethylating agent under the catalysis of tetramethylammonium fluoride. The overall yields were 82%, 76%; 54%, 62%; and 27%, 25%, respectively. The alpha-configuration of trifluoromethyl group of 17-position was determined by X-ray crystal diffraction method. Compounds la, 2a and 3a showed high affinity for rat uterus PRc. The test of biological activities of compounds Ib, 2b and 3b is proceeding.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25777
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Wang ZQ,Lu SF,Zhang JR. Synthesis and properties of trifluoromethylating steroid compounds[J]. Sci. China Ser. B-Chem.,1997,40(3):294-301.
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