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学科主题: 生命有机化学
题名: Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning
其他题名: Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning
作者: He QL(贺庆利) ; Jiang H(江辉) ; Zhang F(张凤) ; Chen HB(陈海宝) ; Tang GL(唐功利)
通讯作者: 唐功利
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2008
卷: 18, 期:14, 页:3995-3998
收录类别: SCI
部门归属: 中科院上海有机所
英文摘要: Simultaneously isolating more than one receptor of natural product remains a challenge to chemical genetics. Using cyclosporine A as an affinity probe and an optimized phage display cloning procedure, not only cyclophilin A, but also cyclophilin B was isolated as the full-length gene clone from a human brain cDNA library. This optimized protocol can be used to select protein targets of chemicals dependent on the binding affinity rather than on the relative abundance in cells. (c) 2008 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000257640400037
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25755
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
He QL,Jiang H,Zhang F,et al. Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning[J]. Bioorg. Med. Chem. Lett.,2008,18(14):3995-3998.
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