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学科主题: 天然产物有机化学
题名: Asymmetric synthesis of (+)-pyrido[3,4-b]homotropane
其他题名: Asymmetric synthesis of (+)-pyrido[3,4-b]homotropane
作者: Sang YX(桑迎霞) ; Zhao JR(赵景瑞) ; Jia XS(贾学顺) ; Zhai HB(翟宏斌)
通讯作者: 翟宏斌
刊名: J. Org. Chem.
发表日期: 2008
卷: 73, 期:9, 页:3589-3592
收录类别: SCI
部门归属: 中国科学院上海有机所; 上海大学; 北京大学药学院
英文摘要: (+)-Pyrido[3,4-b]homotropane (PHT) was efficiently constructed in 12 steps from N,N-diisopropylisonicotinamide. The synthesis features (i) RCM reaction in installing the homotropane skeleton, (ii) Snieckus ortho-lithiation of N,N-diisopropylisonicotinamide followed by acylation, (iii) Myer reduction of bulky tertiary amide to alcohol with LiBH3NH2, and (iv) utilization of L-glutamic acid to introduce and establish the requisite stereogenic centers.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000255339600041
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25603
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Sang YX,Zhao JR,Jia XS,et al. Asymmetric synthesis of (+)-pyrido[3,4-b]homotropane[J]. J. Org. Chem.,2008,73(9):3589-3592.
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