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学科主题: 天然产物有机化学
题名: Synthesis of conformationally restricted nicotine analogues by intramolecular [3+2] cycloaddition
其他题名: Synthesis of conformationally restricted nicotine analogues by intramolecular [3+2] cycloaddition
作者: Yang XB(杨小宝) ; Luo SJ(罗盛军) ; Fang F(方芳) ; Liu P(刘澎) ; Lu Y(路勇) ; He MY(何鸣元) ; Zhai HB(翟宏斌)
通讯作者: 翟宏斌
刊名: Tetrahedron
发表日期: 2006
卷: 62, 期:10, 页:2240-2246
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 华东师范大学
英文摘要: We describe the synthesis of a series of conformationally constrained nicotine analogues 2-5 from appropriate pyridine-containing enals, featuring an intramolecular azomethine ylide-alkene [3 + 2] cycloaddition. The objective of the current project is to develop new selective nAChRs-targeting ligands. Of the nicotine analogues that we have studied, the conformation-restricting ring B unit can be either a five-membered carbocycle, or a six-membered carbocycle or heterocycle. The present work constitutes a general method for rapid assembly of other related tricyclic nicotine analogues. (c) 2005 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000235579800011
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25587
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Yang XB,Luo SJ,Fang F,et al. Synthesis of conformationally restricted nicotine analogues by intramolecular [3+2] cycloaddition[J]. Tetrahedron,2006,62(10):2240-2246.
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