中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 中科院天然产物有机化学重点实验室  > 期刊论文
学科主题: 天然产物有机化学
题名: Two efficient four-step routes to marine toxin tanikolide
其他题名: 四步法高效合成海洋毒素 tanikolide 的两条路线
作者: Chen QS(陈庆寿) ; Deng HB(邓海兵) ; Zhao JR(赵景瑞) ; Lu Y(路勇) ; He MY(何鸣元) ; Zhai HB(翟宏斌)
通讯作者: 翟宏斌
刊名: Tetrahedron
发表日期: 2005
卷: 61, 期:35, 页:8390-8393
收录类别: SCI
部门归属: 中科院上海有机化学研究所现代有机合成研究室; 生命有机和天然产物化学国家重点实验室; 华东师范大学化学系绿色化学化工上海重点实验室
英文摘要: We have presented two facile four-step syntheses of (+/-)-tanikolide from ethyl 2-oxocyclopentanecarboxylate. The overall chemical yields of the two sequences reached as high as 76 and 85%, respectively. The first strategy involved alkylation. Baeyer-Villiger reaction. saponification, and reduction/lactonization. The second approach for synthesizing tanikolide took advantage of the same intermediate, the alkylated ketoester 2, which was converted to the target molecule in such three steps is deethoxycarbonylation, hydroxymethylation, and Baeyer-Villiger reaction. Our strategies are advantageous because of their high yields and suitability for the preparation of I in multigram or larger quantities.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000231211800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25581
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2005085.pdf(154KB)----开放获取--View Download

Recommended Citation:
Chen QS,Deng HB,Zhao JR,et al. Two efficient four-step routes to marine toxin tanikolide[J]. Tetrahedron,2005,61(35):8390-8393.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[陈庆寿]'s Articles
[邓海兵]'s Articles
[赵景瑞]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[陈庆寿]‘s Articles
[邓海兵]‘s Articles
[赵景瑞]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2005085.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace