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学科主题: 高分子化学
题名: Antibacterial activity of ciprofloxacin-loaded zein microsphere films
其他题名: Antibacterial activity of ciprofloxacin-loaded zein microsphere films
作者: FU JIANXI ; Wang HJ(王华杰) ; ZHOU YANQING ; Wang JY(王瑾晔)
通讯作者: 王瑾晔
刊名: Mater. Sci. Eng. C-Biomimetic Supramol. Syst.
发表日期: 2009
卷: 29, 期:4, 页:1161-1166
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 河南师范大学; 上海交通大学
英文摘要: Our aim was to produce an antibiotic-emitting coating composed of zein microspheres for the prevention of bacterial infection oil implanted devices. Ciprofloxacin-loaded zein microspheres were prepared using a phase separation procedure, with particle sizes between 0.5 and 2 mu m. Drug encapsulation and drug loading varied with the amount of both zein and ciprofloxacin. and the highest encapsulation efficiency was 8.27% (2 mg/ml ciprofloxacin and 20 mg/ml zein: n = 3). A ciprofloxacin-loaded zein microsphere film (CF-MS film) was generated via solvent evaporation. Continuous drug release from a trypsin-degraded microsphere film was observed for Up to 28 days. The liberation of ciprofloxacin from the trypsin-degraded film and the biodegradation of the microsphere film were highly correlated. Proliferation assay of the growth of human umbilical vein endothelial cells (HUVECs) by the MTT method showed that the microsphere film had no toxicity when compared with cells grown oil Corning Culture plates alone and plates with a zein film alone. Quantification of bacteria adhesion showed that adhesion on the microsphere film is significantly Suppressed. in addition, according to the results of bacterial growth tests, ciprofloxacin-loaded microsphere films maintained antibacterial activity for more than 6 days, In contrast, a control medium containing a zein film allowed constant bacterial growth. These results indicate that CF-MS films might be useful as,antibacterial films oil implanted devices. (C) 2008 Elsevier B.V. All rights reserved.
语种: 英语
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WOS记录号: WOS:000269139900017
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25485
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
FU JIANXI,Wang HJ,ZHOU YANQING,et al. Antibacterial activity of ciprofloxacin-loaded zein microsphere films[J]. Mater. Sci. Eng. C-Biomimetic Supramol. Syst.,2009,29(4):1161-1166.
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