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学科主题: 高分子化学
题名: Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation
其他题名: 蛋白/无机杂化材料成骨性的体外评价
作者: QU ZHIHU ; Wang HJ(王华杰) ; TANG TINGTING ; ZHANG XIAOLING ; Wang JY(王瑾晔) ; DAI KERONG
通讯作者: 王瑾晔 ; DAI KERONG
刊名: Acta Biomater.
发表日期: 2008
卷: 4, 期:5, 页:1360-1368
收录类别: SCI
部门归属: 上海有机所; 上海交通大学; 上海生科院健康所;
英文摘要: We have previously Studied the biocompatibility and mechanical properties of porous zein scaffolds. We based the study oil the concept that composite scaffold materials, especially when combined with inorganic materials, are more Suited to the mechanical and physiological demands of the host tissue than individual scaffold materials. We investigated the effect of zein/inorganic composite on the physical and biological properties of porous zein scaffolds, which were fabricated by salt-leaching. The composite was prepared by immersion in simulated body fluid. The hydroxyapatite (HA)-coated zein scaffold had the same porosity as the zein scaffold (over 75%). Using scanning electron microscopy, it was established that the morphology of pores located on the surface and within the porous scaffolds showed equally good pore interconnectivity with zein. However, the compressive Young's modulus decreased from 240.1 +/- 96.8 to 34.4 +/- 12.6 MPa, and compressive strength decreased from 7.8 +/- 1.2 to 4.2 +/- 0.8 MPa. From the in vitro test with human bone marrow stroma. cells, the osteoblastic differentiation on the surface of the HA-coated zein scaffold was increased. Lis expressed by the alkaline phosphatase activity and reverse trail scription-polymerase chain reaction analysis for marker genes. From both the mechanical and biological evaluations, the HA-coated zein scaffold was found to be the optimal biomaterial for bone tissue engineering. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000259740400024
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25469
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
QU ZHIHU,Wang HJ,TANG TINGTING,et al. Evaluation of the zein/inorganics composite on biocompatibility and osteoblastic differentiation[J]. Acta Biomater.,2008,4(5):1360-1368.
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