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学科主题: 高分子化学
题名: Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products
其他题名: Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products
作者: LIU WEI ; Wang HJ(王华杰) ; WANG LIPING ; LIU SHANLIN ; Wang JY(王瑾晔)
通讯作者: 王瑾晔
刊名: BBA-Proteins Proteomics
发表日期: 2007
卷: 1774, 期:2, 页:258-266
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 上海交通大学
英文摘要: In the present study, the formation of modified proteins by methyl docosahexaenoate (DHA) peroxidation products in the presence of a metalcatalyzed oxidation system was investigated. Metal-catalyzed oxidation of mixtures containing bovine serum albumin (BSA) and DHA led to formation of two high molecular weight derivatives of BSA. One had a mass of 71.5 kDa as determined by two-dimensional electrophoresis, matrix assisted laser desorption and ionization mass spectrometer (MALDI MS) analysis. The other was estimated to be 93 kDa by SDS-PAGE electrophoresis. The exposure of BSA to DHA also led to the generation of carbonyl groups. Oxygen radical scavengers could inhibit these modifications induced by DHA peroxidation. Furthermore, there was little difference of the peptides mass fingerprinting between the two kinds of modified high-molecular-weight proteins. These results suggest that oxygen radicals formed during lipid peroxidation are involved in the formation of protein derivatives. Our study may be important in the understanding the specific role of docosahexaenoic acid in the formation of modified proteins during aging and its related diseases. (c) 2006 Elsevier B.V All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000244638900009
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25463
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
LIU WEI,Wang HJ,WANG LIPING,et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products[J]. BBA-Proteins Proteomics,2007,1774(2):258-266.
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