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学科主题: 高分子化学
题名: Effect of asymmetric distribution of phospholipids in ghost membrane from rat blood on peroxidation induced by ferrous ion
其他题名: 大鼠红血球膜磷脂的不对称分布和过氧化
作者: Di L(狄伶) ; Liu W(刘薇) ; Liu Y(刘宇) ; Wang JY(王瑾晔)
通讯作者: 王瑾晔
刊名: FEBS Lett.
发表日期: 2006
卷: 580, 期:2, 页:685-690
收录类别: SCI
部门归属: 上海交大; 上海有机所
英文摘要: This study used rat erythrocyte ghost membrane to investigate the effect of aminophospholipid distribution in biological membranes on oxidative susceptibility. Aminophospholipids, lipid peroxidation, and carbonyl compounds were quantified; plasma membrane structure was examined using atomic force microscopy (AFM) and SDS-polyacrylamide gel electrophoresis (SDS-PAGE). Inside-out vesicles (IOVs) had significantly more aminophospholipids and greater lipid peroxidation than rightside-out vesicles (ROVs). Spectrin bands in IOVs disappeared obviously than in ROVs as shown in SDS-PAGE. In both systems vesicle protein size increased significantly with oxidation. Proteins aggregated much more in IOVs than ROVs at 48 h. These observations suggest that IOVs were more susceptible to ferrous ion-induced peroxidation than ROVs and that asymmetric phospholipid distribution affects biomembranes' oxidative susceptibility. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000234937400053
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25449
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Di L,Liu W,Liu Y,et al. Effect of asymmetric distribution of phospholipids in ghost membrane from rat blood on peroxidation induced by ferrous ion[J]. FEBS Lett.,2006,580(2):685-690.
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