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学科主题: 高分子化学
题名: Mechanical properties and in vitro biocompatibility of porous zein scaffolds
其他题名: 多孔蛋白支架的体外生物相容性和力学性能
作者: Gong SJ(龚生举) ; Wang HJ(王华杰) ; Sun QS(孙庆申) ; Xue ST(薛松涛) ; Wang JY(王瑾晔)
通讯作者: 薛松涛 ; 王瑾晔
刊名: Biomaterials
发表日期: 2006
卷: 27, 期:20, 页:3793-3799
收录类别: SCI
部门归属: 上海交大; 上海有机所
英文摘要: A porous scaffold utilizing hydrophobic protein zein was prepared by the salt-leaching method for tissue engineering. The scaffolds possessed a total porosity of 75.3-79.0%, compressive Young's modulus of (28.2 +/- 6.7)MPa-(86.6 +/- 19.9)MPa and compressive strength of (2.5 +/- 1.2)MPa-(11.8 +/- 1.7)MPa, the percentage degradation of 36% using collagenase and 89% using pepsin during 14 days incubation in vitro. The morphology of pores located on the surface and within the porous scaffolds showed good pore interconnectivity by scanning electron microscopy (SEM). Rat mesebchymal stern cells (MSCs) could adhere, grow, proliferate and differentiate toward osteoblasts on porous zein scaffold. With the action of dexamethasone, the cells showed a relative higher activity of alkaline phosphatase (ALP) and a higher proliferating activity (p < 0.05) than those of MSCs without dexamethasone. (c) 2006 Elsevier Ltd. All rights reserved.
语种: 英语
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WOS记录号: WOS:000237346000011
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25447
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Gong SJ,Wang HJ,Sun QS,et al. Mechanical properties and in vitro biocompatibility of porous zein scaffolds[J]. Biomaterials,2006,27(20):3793-3799.
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