中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 上海有机化学研究所  > 期刊论文
学科主题: 高分子化学
题名: Heparin-loaded zein microsphere film and hemocompatibility
其他题名: 包载肝素的玉米醇溶蛋白微球薄膜及其血液相容性.
作者: Wang HJ(王华杰) ; Lin ZX(林志新) ; Liu XM(刘新铭) ; Sheng SY(盛世彦) ; Wang JY(王瑾晔)
通讯作者: 王瑾晔
刊名: J. Control. Release
发表日期: 2005
卷: 105, 期:1-2, 页:120-131
收录类别: SCI
部门归属: 上海有机化学研究所; 上海交通大学
英文摘要: Zein was studied as a drug-eluting coating film composed of zein microspheres for cardiovascular devices (e.g. stent). In vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) analysis showed that both zein film and its degraded product had better biocompatibility compared with Coming culture plate on the growth of human umbilical veins endothelial cells (HUVECs, p < 0.05, it =6), and the effect of zein degraded product on HUVECs was dose-dependent. The best result was obtained at 0.3 mg/ml of the addition. The encapsulation efficiency of heparin and beparin loading varied with the amount of both zein and heparin, and the highest encapsulation efficiency (heparin 1.33 mg/ml and zein 16 mg/ml) was 22.77 +/- 1.33% (n = 3). Scanning electron microscope (SEM) observation indicated that the zein film was made of microspheres in diameter from nano- to micrometer, which could be controlled. Sizes of heparin-loaded zein microspheres changed before and after release of heparin because of conglutination among zein microspheres. Release rate of heparin from microsphere film reached to 33.5 +/- 1.2% within 12 h, and began to get into subsequent "slow release"phase; about 55% of the entrapped heparin was released after 20 days. Both zein film and heparin-loaded zein microsphere film were effective in suppressing platelet adhesion, and the heparin-loaded film showed a better anticoagulation as determined with thrombin time (TT) assay. These results suggest that zein film could be used directly as a new type of coating material for its better biocompatibility with HUVECs. Moreover, the heparin-loaded zein microsphere film can significantly improve the hemocompatibility. (c) 2005 Elsevier B.V. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000230576600011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25429
Appears in Collections:上海有机化学研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2005118.pdf(575KB)----开放获取--View Download

Recommended Citation:
Wang HJ,Lin ZX,Liu XM,et al. Heparin-loaded zein microsphere film and hemocompatibility[J]. J. Control. Release,2005,105(1-2):120-131.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[王华杰]'s Articles
[林志新]'s Articles
[刘新铭]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[王华杰]‘s Articles
[林志新]‘s Articles
[刘新铭]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2005118.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace