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学科主题: 生命有机化学
题名: Modifications of protein by polyunsaturated fatty acid ester peroxidation products
其他题名: 多不饱和脂肪酸酯过氧化产物对蛋白质的修饰
作者: Liu W(刘薇) ; Wang JY(王瑾晔)
通讯作者: 王瑾晔
刊名: BBA-Proteins Proteomics
发表日期: 2005
卷: 1752, 期:1, 页:93-98
收录类别: SCI
部门归属: 上海有机化学研究所; 上海交通大学
英文摘要: The ability of unsaturated fatty acid methyl esters to modify bovine serum albumin (BSA) in the presence of a metal-catalyzed oxidation system [ascorbic acid/Fe (II)/O-2] was investigated. The exposure of BSA to PUFA esters led to the generation of carbonyl groups and the formation of high-molecular-weight proteins, which were strongly dependent on the degree of fatty acid unsaturation. The high-molecular-weight proteins were detected by Western blot analysis and were not recognized by five antibodies. The observation that levels of conjugated dienes and malondialdehyde formed in the presence of BSA were substantially lower in the presence than in the absence of BSA indicated that radicals formed during the degradation of lipid hydroperoxides are likely involved in the formation of protein derivatives. These results may be important in understanding the specific roles of different polyunsaturated fatty acids in the pathophysiological effects associated with oxidative stress. (c) 2005 Elsevier B.V All rights reserved.
语种: 英语
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WOS记录号: WOS:000231753500012
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25425
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Liu W,Wang JY. Modifications of protein by polyunsaturated fatty acid ester peroxidation products[J]. BBA-Proteins Proteomics,2005,1752(1):93-98.
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