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学科主题: 高分子化学
题名: Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility
其他题名: 醇溶蛋白作为组织工程材料的基础研究
作者: Dong J(董健) ; Sun QS(孙庆申) ; Wang JY(王瑾晔)
通讯作者: 王瑾晔
刊名: Biomaterials
发表日期: 2004-01-01
卷: 25, 期:19, 页:4691-4697
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 上海交通大学
英文摘要: The zein films, were prepared for culturing human liver cells (HL-7702) and mice fibroblast cells (NIH3T3), while the Corning microplate and polylactic acid (PLA) were chosen as controls. The surface morphology of zein films prepared by two different methods was studied by scanning electron microscope (SEM), which revealed that the zein films were composed of particles of diameter 100-500 and 500-2500 nm, respectively. The biocompatibility of zein films was assessed by attachment, extensibility and proliferation of cells on them. Our study indicated that over 60% of both HL-7702 cells and NlH3T3 cells could attach to the Corning microplate, zein films and PLA at 3 h after seeding. The concentration and particle sizes for preparing zein films did not seem to affect the proliferation of the cells tested. There were no significant differences in the proliferation of both HL-7702 cells and NIH3T3 cells between the Corning microplate and two kinds of zein films, except that the zein film composed of smaller particles at the lowest concentration exhibited a very good ability for proliferation of both the cells, while PLA was a poor matrix in the latter period of the cell proliferation. This preliminary study demonstrates that zein is a promising biomaterial with good biocompatibility for the development of tissue engineering. (C) 2003 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000221211400020
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25423
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Dong J,Sun QS,Wang JY. Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility[J]. Biomaterials,2004,25(19):4691-4697.
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