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学科主题: 生命有机化学
题名: Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats
其他题名: 食用DHA及抗坏血或对ODS大鼠视网膜氧化 进展
作者: Wang JY(王瑾晔) ; Sekine S ; Saito M
通讯作者: 王瑾晔
刊名: Free Radic. Res.
发表日期: 2003-01-01T00:00:00Z
卷: 37, 期:4, 页:419-424
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 日本国立健康营养研究所
英文摘要: Mutant male osteogenic disorder Shionogi (ODS) rats, unable to synthesize ascorbic acid, were fed diets containing a high content of docosahexaenoic acid (DHA) and different amounts of ascorbic acid, to study the effect of DHA on peroxidative susceptibility of the retina and possible antioxidant action of ascorbic acid. ODS rats were fed from 7 weeks of age with diets containing high DHA (6.4% of total energy). A control group received a diet high in linoleic acid. The diets also contained varying amounts of ascorbic acid. Fatty acid compositions and phospholipid hydroperoxides in rod outer segment (ROS) membranes, and retinal ascorbic acid were analyzed. DHA in ROS membranes was significantly increased in rats fed high DHA, compared with the linoleic acid diet. Levels of phospholipid hydroperoxides in the DHA-fed rats were significantly higher than the linoleic acid-fed rats. Ascorbic acid supplementation did not suppress the phospholipid hydroperoxide levels after a high DHA diet, even when the supplement increased the content of retinal ascorbic acid. In conclusion, high DHA feeding induced a marked increase of phospholipid hydroperoxides in ROS membranes of ODS rats. Supplementation of ascorbic acid did not reverse this increase.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25419
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Wang JY,Sekine S,Saito M. Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats[J]. Free Radic. Res.,2003,37(4):419-424.
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