SIOC OpenIR  > 上海有机化学研究所
Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats
其他题名食用DHA及抗坏血或对ODS大鼠视网膜氧化 进展
Wang JY(王瑾晔); Sekine S; Saito M
2003
发表期刊Free Radic. Res.
ISSN1071-5762
卷号37期号:4页码:419-424
摘要Mutant male osteogenic disorder Shionogi (ODS) rats, unable to synthesize ascorbic acid, were fed diets containing a high content of docosahexaenoic acid (DHA) and different amounts of ascorbic acid, to study the effect of DHA on peroxidative susceptibility of the retina and possible antioxidant action of ascorbic acid. ODS rats were fed from 7 weeks of age with diets containing high DHA (6.4% of total energy). A control group received a diet high in linoleic acid. The diets also contained varying amounts of ascorbic acid. Fatty acid compositions and phospholipid hydroperoxides in rod outer segment (ROS) membranes, and retinal ascorbic acid were analyzed. DHA in ROS membranes was significantly increased in rats fed high DHA, compared with the linoleic acid diet. Levels of phospholipid hydroperoxides in the DHA-fed rats were significantly higher than the linoleic acid-fed rats. Ascorbic acid supplementation did not suppress the phospholipid hydroperoxide levels after a high DHA diet, even when the supplement increased the content of retinal ascorbic acid. In conclusion, high DHA feeding induced a marked increase of phospholipid hydroperoxides in ROS membranes of ODS rats. Supplementation of ascorbic acid did not reverse this increase.
学科领域生命有机化学
部门归属中国科学院上海有机化学研究所; 日本国立健康营养研究所
URL查看原文
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/25419
专题上海有机化学研究所
通讯作者Wang JY(王瑾晔)
推荐引用方式
GB/T 7714
Wang JY,Sekine S,Saito M. Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats[J]. Free Radic. Res.,2003,37(4):419-424.
APA 王瑾晔,Sekine S,&Saito M.(2003).Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats.Free Radic. Res.,37(4),419-424.
MLA 王瑾晔,et al."Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats".Free Radic. Res. 37.4(2003):419-424.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2004361.pdf(407KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[王瑾晔]的文章
[Sekine S]的文章
[Saito M]的文章
百度学术
百度学术中相似的文章
[王瑾晔]的文章
[Sekine S]的文章
[Saito M]的文章
必应学术
必应学术中相似的文章
[王瑾晔]的文章
[Sekine S]的文章
[Saito M]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。