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Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging
其他题名用于磁共振显像的、生物相容性和多功能的PCL-b-PAA共聚物均一杂化胶束的制备
Niu DC(牛德超); Liu XH(刘晓航); Li YS(李永生); Ma Z(马志); Dong WJ(董文杰); Chang S(常舒); Zhao WR(赵文茹); Gu JL(顾金楼); Zhang SJ(张胜建); Shi JL(施剑林)
2011
发表期刊J. Mater. Chem.
ISSN0959-9428
卷号21期号:36页码:13825-13831
摘要In this paper, a simple strategy was developed to fabricate a novel kind of uniform, biocompatible and PEGylated multifunctional hybrid micelles with multiple magnetite nanocrystal loaded cores and dye-doped silica cross-linked shells based on the self-assembly between poly(epsilon-caprolactone)-b-poly(acrylic acid) copolymer and inorganic nanoparticles. The loading of multiple magnetite nanoparticles in the core part of the hybrid micelles endows them with T2-weighted MR imaging functionalities. Small dye molecules (Rhodamine B) were directly incorporated into the silica layer framework during the cross-linking process, imparting the hybrid micelles with fluorescent imaging modality. Poly(ethylene glycol) (PEG) was grafted to reduce the phagocytic capture of nanoparticles by cellular components of the immune system. Importantly, the potential application of magnetite incorporated PEGylated hybrid micelles as T2 contrast agents for MRI was demonstrated both in vitro and in vivo, with the passive targeting behavior via EPR effect due to the leaky vasculature and poor lymphatic drainage in tumors.
学科领域高分子化学
部门归属华东理工大学材料科学与工程学院超细材料教育部重点实验室; 复旦大学肿瘤医院放射科; 中国科学院上海有机化学研究所; 中国科学院上海硅酸盐研究所高性能陶瓷与超细微结构国家重点实验室
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收录类别SCI
语种英语
WOS记录号WOS:000294441300016
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/25409
专题分析化学研究室
通讯作者Li YS(李永生)
推荐引用方式
GB/T 7714
Niu DC,Liu XH,Li YS,et al. Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging[J]. J. Mater. Chem.,2011,21(36):13825-13831.
APA 牛德超.,刘晓航.,李永生.,马志.,董文杰.,...&施剑林.(2011).Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging.J. Mater. Chem.,21(36),13825-13831.
MLA 牛德超,et al."Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging".J. Mater. Chem. 21.36(2011):13825-13831.
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