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学科主题: 高分子化学
题名: Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging
其他题名: 用于磁共振显像的、生物相容性和多功能的PCL-b-PAA共聚物均一杂化胶束的制备
作者: Niu DC(牛德超) ; Liu XH(刘晓航) ; Li YS(李永生) ; Ma Z(马志) ; Dong WJ(董文杰) ; Chang S(常舒) ; Zhao WR(赵文茹) ; Gu JL(顾金楼) ; Zhang SJ(张胜建) ; Shi JL(施剑林)
通讯作者: 李永生
刊名: J. Mater. Chem.
发表日期: 2011
卷: 21, 期:36, 页:13825-13831
收录类别: SCI
部门归属: 华东理工大学材料科学与工程学院超细材料教育部重点实验室; 复旦大学肿瘤医院放射科; 中国科学院上海有机化学研究所; 中国科学院上海硅酸盐研究所高性能陶瓷与超细微结构国家重点实验室
英文摘要: In this paper, a simple strategy was developed to fabricate a novel kind of uniform, biocompatible and PEGylated multifunctional hybrid micelles with multiple magnetite nanocrystal loaded cores and dye-doped silica cross-linked shells based on the self-assembly between poly(epsilon-caprolactone)-b-poly(acrylic acid) copolymer and inorganic nanoparticles. The loading of multiple magnetite nanoparticles in the core part of the hybrid micelles endows them with T2-weighted MR imaging functionalities. Small dye molecules (Rhodamine B) were directly incorporated into the silica layer framework during the cross-linking process, imparting the hybrid micelles with fluorescent imaging modality. Poly(ethylene glycol) (PEG) was grafted to reduce the phagocytic capture of nanoparticles by cellular components of the immune system. Importantly, the potential application of magnetite incorporated PEGylated hybrid micelles as T2 contrast agents for MRI was demonstrated both in vitro and in vivo, with the passive targeting behavior via EPR effect due to the leaky vasculature and poor lymphatic drainage in tumors.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000294441300016
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/25409
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Niu DC,Liu XH,Li YS,et al. Fabrication of uniform, biocompatible and multifunctional PCL-b-PAA copolymer-based hybrid micelles for magnetic resonance imaging[J]. J. Mater. Chem.,2011,21(36):13825-13831.
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