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高效液相色谱手性冠醚固定相拆分丙氨酸、正缬氨酸和犬尿氨酸对映体
Alternative TitleEnantioseparation of Alanine, Norvaline and Kynurenine by High Performance Liquid Chromatography Using Chiral Crown ether Stationary Phase
李齐; 林琳; 唐民华; 许旭
2009
Source Publication分析化学
ISSN0253-3820
Volume37Issue:6Pages:919-922
Other AbstractEnantiomers of alanine, norvaline and kynurenine were separated by HPLC using chiral CROWN-PAK CR (+) column. Three chiral samples can be separated using pH 1.0 perchloric acid aqueous solution as mobile phase, 20 degrees C as column temperature, and 1.0 mL/min as flow rate. Alanine, norvaline and kynurenine were detected at the wavelengths of 200, 220 and 254 nm, respectively. The effects of flow rate, temperature and pH for separation were investigated. Experimental results show that the lower temperature helps to chiral selectivity, but it also reduces column performance, thereby affectes chiral resolution. The relationship between Ink', Ina and 1/T was studied in 0 - 20 degrees C degrees column temperature. The enatioseparation thermodynamic functions of the three enantiomers were calculated.
Subject Area分析化学
Department中国科学院上海有机化学研究所
Indexed BySCI
Language中文
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/24779
Collection上海有机化学研究所
Corresponding Author许旭
Recommended Citation
GB/T 7714
李齐,林琳,唐民华,等. 高效液相色谱手性冠醚固定相拆分丙氨酸、正缬氨酸和犬尿氨酸对映体[J]. 分析化学,2009,37(6):919-922.
APA 李齐,林琳,唐民华,&许旭.(2009).高效液相色谱手性冠醚固定相拆分丙氨酸、正缬氨酸和犬尿氨酸对映体.分析化学,37(6),919-922.
MLA 李齐,et al."高效液相色谱手性冠醚固定相拆分丙氨酸、正缬氨酸和犬尿氨酸对映体".分析化学 37.6(2009):919-922.
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