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学科主题: 分析化学
题名: Study on the precipitation reaction between baicalin and berberine by HPLC AND LIFE SCIENCES
其他题名: 高效液相色谱法研究黄芩苷和小檗碱的沉淀反应
作者: Li Y(李奕) ; Xu X(许旭)
通讯作者: 许旭
刊名: J. Chromatogr. B
发表日期: 2004-01-01
卷: 810, 期:1, 页:165-168
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: The solubility product equilibrium constant for the precipitation between baicalin and berberine was investigated because of the current interest in decocting process of complex prescription of Chinese herbal medicine. HPLC was used for determining two compounds' equilibrium concentrations at different precipitate conditions to calculate thermodynamic constants and study kinetic process. The analysis was performed on a Kromasil C-18 column with TEA-adjusted 0.02 mol/L H3PO4 (pH 4.82)-acetonitrile (75:25) as mobile phase at a flow-rate of 1.0 ml/min, with detection at 254 nm. According to the experiment result, the molar ratio of baicalin and berberine in precipitate is about 1:1. The experimental K-sp values are (1.01 +/- 0.12) x 10(-9) mol(2)/L-2 at 20degreesC in 0.02 mol/L NaH2PO4-Na2HPO4 (pH 4.82), and (3.20 +/- 0.46) x 10(-9) mol(2)/L-2 at 40degreesC in the same buffer. The precipitate reaction is an exothermic process and occurs immediately, even though the precipitate cannot be observed in time because the precipitate is light, yellow, flocculous and suspending in the yellow solution. (C) 2004 Elsevier B.V. All rights reserved.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24723
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Li Y,Xu X. Study on the precipitation reaction between baicalin and berberine by HPLC AND LIFE SCIENCES[J]. J. Chromatogr. B,2004,810(1):165-168.
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