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学科主题: 生命有机化学
题名: Anti-HIV-1 activity of trichobitacin, a novel ribosome-inactivating protein
其他题名: 具有抗HIV-1活性的新核糖体失活蛋白-栝楼蛋白
作者: Zheng YT(郑永唐) ; Bi KL(贲昆龙) ; Jin SW(金善炜)
通讯作者: 贲昆龙
刊名: Acta Pharmacol. Sin.
发表日期: 2000
卷: 21, 期:2, 页:179-0182
收录类别: SCI
部门归属: 中国科学院昆明动物研究所;中国科学院上海有机化学研究所
英文摘要: To determine whether trichobitacin, a novel ribosome-inactivating protein purified from the root tubers of trichosanthes kirlowii, possesses the anti-HIV activity. Methods: the inhibition of syncytial cell formaion induced by human immunodeficiency virus type 1 (HIV-1) was determined under microscope, reduction of HIV-1P24 antigen expression level was measured by ELISA, and decrease in numbers of HIV-1 antigen positive cells in acutely and chronically infected cultures were detected by indirect immunofluorescence assay. Results: Trichobitacin was found to greatly suppres syncytial cell formation induced by HIV-1 and to markedly reduce both expression HIV-1 p24 antigen and the number of HIV-1antigen positive cells in acutely but not chronically HIV-1 infected culture. The median inhibitory concentration (IC^50) in inhibition of syncytial cell formation and HIV antigen positive cells were 5 μg.L-1(95 % confidence limits: 1,3-20 μg.L-1) and 0.09 mg.L-~1(95% confidence limits: 0.011-0.755 mg.L~1), respectively. Conclusion: Trichobitacin is a novel ribosome-inactivating protein with anti-HIV-1activity.
语种: 英语
WOS记录号: WOS:000085208200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24711
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zheng YT,Bi KL,Jin SW. Anti-HIV-1 activity of trichobitacin, a novel ribosome-inactivating protein[J]. Acta Pharmacol. Sin.,2000,21(2):179-0182.
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