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学科主题: 生命有机化学
题名: Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes
其他题名: α库瓜子蛋白抑制急性感染而不抑制慢性感染T淋巴细胞中HIV-1的复制
作者: Zheng YT(郑永唐) ; Bi KL(贲昆龙) ; Jin SW(金善炜)
通讯作者: 贲昆龙
刊名: Acta Pharmacol. Sin.
发表日期: 1999
卷: 20, 期:3, 页:239-243
收录类别: SCI
部门归属: 中国科学院昆明动物所; 中国科学院上海有机化学研究所
英文摘要: To identify the anti-human immunodeficiency virus type 1 (HIV-1) activities of α-momorcharin (α-MMC) from momordica charantia in acutely and chronically infected Tlymphocytes. METHODS: The anti-HIV activities of -MMC were examined by 1) the inhibition of syncytia formation inducedby HIV-1 ⅢB; 2) reduction of p24 core antigen expression level and decrease in numbers of HIV antigen positive cells in acutely and chronically infected cultures. The cytotoxic effects of α-MMC was tested by trypan blue dye exclusion or colorimetric MTT assay. RESULTS: α-MMC wasfound to obviously inhibit HIV-1 ⅢB-inducing C8166 syncytia formation and markedly reduced both expression of p24 core antigen and the numbers of HIV antigen positive cells in acutely but not chronically HIV-1-infected culture. The median effective concentration (EC=50) in these assays were 0.016, 0.07, and 0.32 mg.L^1, respectively. CONCLUSION: α-MMC is a unique component of momorcharin with anti-HIV activity, and markedly inhibited HIV-1replication in acutely but not chronically HIV-1-infected T-lymphocytes.
语种: 英语
WOS记录号: WOS:000079115400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24709
Appears in Collections:上海有机化学研究所_期刊论文

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Recommended Citation:
Zheng YT,Bi KL,Jin SW. Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes[J]. Acta Pharmacol. Sin.,1999,20(3):239-243.
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