Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin
其他题名Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin
Wang ZY(王兆彦); Xu XX(许杏祥); Hu ZD(胡之德); Kang JW(康经武)
2006
发表期刊Chin. J. Chem.
ISSN1001-604X
卷号24期号:10页码:1384-1387
摘要A sensitive method for enantioseparation of a basic drug rivastigmine and determination of its optical impurity by capillary electrophoresis with highly sulfated beta-cyclodextrin (HS-beta-CD) as the chiral selector is described. In general, enantioseparation of basic chiral compounds is carried out in acidic condition (pH 2.5) to prevent analytes from adsorption on the capillary wall. However, in the case of rivastigmine, the detection sensitivity was too limited to determine the optical impurity of S-rivastigmine lower than 1% when buffer pH was 2.5. It was found that the detection sensitivity was improved 1.6 times just by raising the buffer pH value from 2.5 to 5.8. The poor column efficiency due to the adsorption of the analytes on the capillary wall was resolved by using dynamical coating of the capillary wall with the linear polyacrylamide solution. The experimental parameters such as the concentration of HS-beta-CD, buffer pH and buffer ionic strength were optimized, respectively. The method was validated in terms of repeatability, linearity, limit of detection (LOD) and limit of quantitation (LOQ). Using the present method, the optical purity of nonracemic rivastigmine with the enantiomeric excess (ee) value of 99.14% was determined.
学科领域有机化学
部门归属兰州大学; 上海有机所
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收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/24357
专题中科院天然产物有机化学重点实验室
通讯作者Kang JW(康经武)
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GB/T 7714
Wang ZY,Xu XX,Hu ZD,et al. Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin[J]. Chin. J. Chem.,2006,24(10):1384-1387.
APA 王兆彦,许杏祥,胡之德,&康经武.(2006).Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin.Chin. J. Chem.,24(10),1384-1387.
MLA 王兆彦,et al."Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin".Chin. J. Chem. 24.10(2006):1384-1387.
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