SIOC OpenIR  > 中科院天然产物有机化学重点实验室
Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin
Alternative TitleSensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin
Wang ZY(王兆彦); Xu XX(许杏祥); Hu ZD(胡之德); Kang JW(康经武)
2006-01-01
Source PublicationChin. J. Chem.
ISSN1001-604X
Volume24Issue:10Pages:1384-1387
AbstractA sensitive method for enantioseparation of a basic drug rivastigmine and determination of its optical impurity by capillary electrophoresis with highly sulfated beta-cyclodextrin (HS-beta-CD) as the chiral selector is described. In general, enantioseparation of basic chiral compounds is carried out in acidic condition (pH 2.5) to prevent analytes from adsorption on the capillary wall. However, in the case of rivastigmine, the detection sensitivity was too limited to determine the optical impurity of S-rivastigmine lower than 1% when buffer pH was 2.5. It was found that the detection sensitivity was improved 1.6 times just by raising the buffer pH value from 2.5 to 5.8. The poor column efficiency due to the adsorption of the analytes on the capillary wall was resolved by using dynamical coating of the capillary wall with the linear polyacrylamide solution. The experimental parameters such as the concentration of HS-beta-CD, buffer pH and buffer ionic strength were optimized, respectively. The method was validated in terms of repeatability, linearity, limit of detection (LOD) and limit of quantitation (LOQ). Using the present method, the optical purity of nonracemic rivastigmine with the enantiomeric excess (ee) value of 99.14% was determined.
Subject Area有机化学
Department兰州大学; 上海有机所
URL查看原文
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/24357
Collection中科院天然产物有机化学重点实验室
Corresponding AuthorKang JW(康经武)
Recommended Citation
GB/T 7714
Wang ZY,Xu XX,Hu ZD,et al. Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin[J]. Chin. J. Chem.,2006,24(10):1384-1387.
APA 王兆彦,许杏祥,胡之德,&康经武.(2006).Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin.Chin. J. Chem.,24(10),1384-1387.
MLA 王兆彦,et al."Sensitive method for enantioseparation of rivastigmine with highly sulfated cyclodextrin as chiral selector by capillary electrophoresis sulfated beta-cyclodextrin".Chin. J. Chem. 24.10(2006):1384-1387.
Files in This Item:
File Name/Size DocType Version Access License
2006013.pdf(52KB) 开放获取--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[王兆彦]'s Articles
[许杏祥]'s Articles
[胡之德]'s Articles
Baidu academic
Similar articles in Baidu academic
[王兆彦]'s Articles
[许杏祥]'s Articles
[胡之德]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[王兆彦]'s Articles
[许杏祥]'s Articles
[胡之德]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.