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学科主题: 氟化学
题名: Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me(3)SiCF(2)H at Ambient or Low Temperature
其他题名: 在室温或低温下利用TMSCF2H试剂对羰基化合物和亚胺的高效直接二氟甲基化
作者: Zhao YC(赵延川) ; Huang WZ(黄维洲) ; Zheng J(郑吉) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: Org. Lett.
发表日期: 2011-01-01
卷: 13, 期:19, 页:5342-5345
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Since 1995, Me(3)SiCF(2)H has been widely believed to be an inefficient difluoromethylating agent, which requires harsh reaction conditions to cleave its rather inert Si-CF(2)H bond. However, it has now been found that, by using a proper Lewis base activator, Me(3)SiCF(2)H can efficiently difluoromethylate various aldehydes, ketones, and imines to give the corresponding products in good to excellent yields at room temperature or even at -78 degrees C.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24099
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Zhao YC,Huang WZ,Zheng J,et al. Efficient and Direct Nucleophilic Difluoromethylation of Carbonyl Compounds and Imines with Me(3)SiCF(2)H at Ambient or Low Temperature[J]. Org. Lett.,2011,13(19):5342-5345.
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