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学科主题: 氟化学
题名: Selective Nucleophilic Fluoroalkylations Facilitated by Removable Activation Groups
其他题名: 可离去的活化基团辅助下的选择性亲核氟烷基化反应
作者: Ni CF(倪传法) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: Synlett
发表日期: 2011
期: 6, 页:770-782
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Selective incorporation of fluorine atoms or fluorine-containing moieties into organic molecules has become a routine and powerful strategy in drug design and new functional-material development. Nucleophilic fluoroalkylation, typically involving the transfer of a fluorinated carbanion or carbanion equivalent to an electrophile, is one of the most important and frequently used methods to synthesize fluorinated organic molecules. In this Account, we introduce some recent achievements in the field of nucleophilic di- and monofluoroalkylation chemistry with functionalized fluoroalkylation reagents. In particular, the effect of fluorine substitution on the reactivity of carbanions is discussed, and several strategies for improving nucleophilic fluoroalkylations are proposed and successfully applied in various new nucleophilic fluoroalkylation reactions. It was found that attaching a removable activation group (such as the phenylsulfonyl group) to a fluorinated carbanion is an important approach to improve the latter's reactivity.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000289122000004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24093
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Ni CF,Hu JB. Selective Nucleophilic Fluoroalkylations Facilitated by Removable Activation Groups[J]. Synlett,2011(6):770-782.
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