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学科主题: 氟化学
题名: Highly Diastereoselective Synthesis of alpha-Difluoromethyl Amines from N-tert-Butylsulfinyl Ketimines and Difluoromethyl Phenyl Sulfone
其他题名: 利用叔丁基亚磺酰亚胺和二氟甲基苯基砜高度非对映选择性制备α-二氟甲基手性胺
作者: Liu J(刘俊) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: Chem.-Eur. J.
发表日期: 2010
卷: 16, 期:37, 页:11443-11454
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: The first highly efficient and stereoselective difluoromethylation of structurally diverse N-tert-butylsulfinyl ketimines has been achieved with an in situ generated PhSO2CF2- anion, which provides a powerful synthetic method for the preparation of a variety of structurally diverse homochiral alpha-difluoromethyl tertiary carbinamines, including alpha-difluoromethyl allylic amines and alpha-difluoromethyl propargylamines. The stereocontrol mode of the present diastereoselective difluoromethylation of ketimines was found to be different from that of other known fluoroalkylations of N-tert-butylsulfinyl aldimines, which suggests that a cyclic six-membered transition state may be involved in the reaction.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000283386600028
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24067
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Liu J,Hu JB. Highly Diastereoselective Synthesis of alpha-Difluoromethyl Amines from N-tert-Butylsulfinyl Ketimines and Difluoromethyl Phenyl Sulfone[J]. Chem.-Eur. J.,2010,16(37):11443-11454.
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