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学科主题: 氟化学
题名: Selective difluoromethylation and monofluoromethylation reactions
其他题名: 选择性二氟甲基化和一氟甲基化反应
作者: Hu JB(胡金波) ; Zhang W(张伟) ; Wang F(王飞)
通讯作者: 胡金波
刊名: Chem. Commun.
发表日期: 2009
期: 48, 页:7465-7478
收录类别: SCI
部门归属: 上海有机所
英文摘要: The selective introduction of fluorine atom(s) and fluorinated moieties into organic molecules has become an important and fast-growing research field, since fluorine atoms play crucial roles in life science and materials science-related applications. Similar to the trifluoromethyl group, both difluoromethyl and monofluoromethyl groups can often bring about many beneficial effects to the target molecules, and a variety of CF2H- and CH2F-containing pharmaceuticals and agrochemicals have been developed. Among the synthetic methods for CF2H- and CH2F-containing compounds, selective di- and monofluoromethylation (i.e., introduction of CF2H and CH2F groups into organic molecules) represent one of the most straightforward synthetic methods and thus can be conveniently used in the synthetic design. This feature article summarizes the presently known selective difluoromethylation and monofluoromethylation methods, including nucleophilic, electrophilic, and free radical di- and monofluoromethylation reagents and reactions.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000272238900002
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24057
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Hu JB,Zhang W,Wang F. Selective difluoromethylation and monofluoromethylation reactions[J]. Chem. Commun.,2009(48):7465-7478.
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