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学科主题: 氟化学
题名: Stereoselective synthesis of alpha-difluoromethyl-beta-amino alcohols via nucleophilic difluoromethylation with Me3SiCF2SO2Ph
其他题名: Stereoselective synthesis of alpha-difluoromethyl-beta-amino alcohols via nucleophilic difluoromethylation with Me3SiCF2SO2Ph
作者: Liu J(刘俊) ; Ni CF(倪传法) ; Wang F(王方) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: Tetrahedron Lett.
发表日期: 2008-01-01
卷: 49, 期:10, 页:1605-1608
收录类别: SCI
部门归属: 中科院上海有机所
英文摘要: A facile synthesis of anti-alpha-(difluoromethyl)-beta-amino alcohols was accomplished by using a nucleophilic difluoromethylation strategy with Me3SiCF2SO2Ph reagent. Good to excellent chemical yields as well as modest to good diastereoselectivity were achieved in these reactions. We found that the solvent played a crucial role in controlling the diastereoselectivity of the reaction, and an apolar solvent such as toluene helps to improve the diastereoselectivity of the reaction. The anti-alpha-(difluoromethyl)-beta-amino alcohol 3a was demonstrated to be a useful synthetic intermediate to synthesize difluoromethylated oxazolidinone 9. (c) 2008 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24041
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Liu J,Ni CF,Wang F,et al. Stereoselective synthesis of alpha-difluoromethyl-beta-amino alcohols via nucleophilic difluoromethylation with Me3SiCF2SO2Ph[J]. Tetrahedron Lett.,2008,49(10):1605-1608.
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