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学科主题: 氟化学
题名: Stereoselective synthesis of di- and monofluoromethylated vicinal ethylenediamines with di- and monofluoromethyl sulfones
其他题名: 利用一氟和二氟甲基砜立体选择性合成含一氟甲基和二氟甲基的手性二胺
作者: Liu J(刘俊) ; Li Y(李亚) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: J. Org. Chem.
发表日期: 2007
卷: 72, 期:8, 页:3119-3121
收录类别: SCI
部门归属: 中科院上海有机所
英文摘要: The diastereoselective nucleophilic (phenylsulfonyl)difluoromethylation and (phenylsulfonyl)monofluoromethylation of alpha-amino N-tert-butanesulfinimines (3) by using PhSO2CF2H and PhSO2CH2F reagents gave products 4 or 5 in high yields (73-99%) and with excellent diastereoselectivity (dr up to > 99:1). After subsequent reductive desulfonylation and acid-catalyzed alcoholysis, compounds 4 and 5 could be readily transformed to chiral alpha-difluoromethylated or alpha-monofluoromethylated ethylenediamines in good yields.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000245510600053
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24019
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Liu J,Li Y,Hu JB. Stereoselective synthesis of di- and monofluoromethylated vicinal ethylenediamines with di- and monofluoromethyl sulfones[J]. J. Org. Chem.,2007,72(8):3119-3121.
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