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学科主题: 氟化学
题名: Facile preparation of difluoromethyl- and monofluoromethyl-containing amides via Ritter reaction
其他题名: 利用Ritter反应制备含二氟甲基和一氟甲基的酰胺类化合物
作者: Liu J(刘俊) ; Ni CF(倪传法) ; Li Y(李亚) ; Zhang LJ(张来俊) ; Wang GY(王冠羽) ; Hu JB(胡金波)
通讯作者: 胡金波
刊名: Tetrahedron Lett.
发表日期: 2006
卷: 47, 期:38, 页:6753-6756
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: Both secondary and tertiary difluoromethylated carbinols were found to readily react with acetonitrile under the catalysis of concentrated sulfuric acid to give the corresponding difluoromethylated acetamides in good yields, which is remarkably more efficient than the previously reported Ritter reactions with corresponding trifluoromethylated carbinols. Similarly, monofluoromethylated and (benzenesulfonyl)difluoromethylated carbinols have shown good reactivity in the Ritter reactions. Since the acetamides can be mildly deacetylated to give amines, the present methodology provides a convenient way for the synthesis of both difluoromethyl- and monofluoromethyl-containing amines starting from simple carbonyl compounds. (c) 2006 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000240670800011
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/24005
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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Recommended Citation:
Liu J,Ni CF,Li Y,et al. Facile preparation of difluoromethyl- and monofluoromethyl-containing amides via Ritter reaction[J]. Tetrahedron Lett.,2006,47(38):6753-6756.
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