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学科主题: 天然产物有机化学
题名: 16S,20S-环氧孕甾-3S-醇乙酸酯的合成及其区域选择性环氧开环取代反应
其他题名: Synthesis of 16S,20S-Epoxypregnane-3S-ol Acetate and Its Regioselective Epoxide-opening Substitution
作者: 韩军 ; 林静容 ; 金荣华 ; 田伟生
通讯作者: 林静容 ; 田伟生
刊名: 化学学报
发表日期: 2011-01-01
卷: 69, 期:19, 页:2272-2280
收录类别: SCI
部门归属: 上海师范大学; 中科院上海有机化学研究所
英文摘要: A synthetic method of 16S,20S-epoxypregnane-3S-ol acetate (4b) from pregnane-3S,16S,20S-triol was developed. Then the epoxide-opening reaction of 4b was investigated under different conditions. The research results showed that 16S,20S-epoxypregnane-3S-ol acetate was chemo-selectively converted into 20R-bromopregnane-3S,16S-diol diacetate, 20R-bromopregnane-3S, 16S-diol-3-acetate, 20R-chloropregnane-3S,16S-diol diacetate, 20R-iodopregnane-3S,16S-dio1-3-acetate and pregnane-3S, 16S,20R-triol-3-acetate. These results not only provided new synthetic intermediates for the syntheses of steroidal drugs and natural steroids, but also presented epoxide-opening methods of steroids with an asymmetric oxetane ring.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/23892
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
韩军,林静容,金荣华,等. 16S,20S-环氧孕甾-3S-醇乙酸酯的合成及其区域选择性环氧开环取代反应[J]. 化学学报,2011,69(19):2272-2280.
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