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学科主题: 氟化学
题名: 氟烷基磺酰氟和(2S,3R)-2,3-二羟基-3-苯基丙酸甲酯的脱水环氧化反应的研究
其他题名: Study of Cyclodehydration of Methyl (2S,3R)-2,3-Dihydroxy-3-Phenylpropionate with Fluoroalkanesulfonyl Fluoride
作者: 严兆华 ; 魏萌 ; 田伟生 ; 官程波
通讯作者: 严兆华 ; 田伟生
刊名: 化学学报
发表日期: 2011-01-01
卷: 69, 期:10, 页:1269-1272
收录类别: SCI
部门归属: 南昌大学; 中科院上海有机化学研究所
英文摘要: The cyclodehydration of methyl (2S,3R)-2,3-dihydroxy-3-phenylpropionate with fluoroalkanesulfonyl fluoride in the presence of an organic base was investigated in detail. The title cyclodehydration resulted in the smooth formation of methyl (2R,3R)-2,3-epoxy-3-phenylpropionate in one step in the yield of 80%similar to 92%, and its enantiomeric excess value is higher than 97%. This new methodology is potentially applicable to industrial manufacturing of methyl (2R,3R)-2,3-epoxy-3-phenylpropionate, a key intermediate for the synthesis of Taxol side chain.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/23884
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
严兆华,魏萌,田伟生,等. 氟烷基磺酰氟和(2S,3R)-2,3-二羟基-3-苯基丙酸甲酯的脱水环氧化反应的研究[J]. 化学学报,2011,69(10):1269-1272.
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