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学科主题: 天然产物有机化学
题名: Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens
其他题名: Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens
作者: JING YU ; XU CHENGGONG ; Ding K(丁凯) ; Lin JR(林静容) ; Jin RH(金荣华) ; Tian WS(田伟生)
通讯作者: 丁凯 ; 田伟生
刊名: Tetrahedron Lett.
发表日期: 2010
卷: 51, 期:24, 页:3242-3245
收录类别: SCI
部门归属: 上海师范大学; 中国科学院上海有机化学研究所
英文摘要: 19-O-Acylation was found to be indispensable for 1,2-dehydrogenation of 19-hydroxyandrost-4-ene-3,17-dione la with DDQ as an oxidant after exploring a variety of C-19 substituents. 1,2-Dehydrogenation in combination with subsequent A-ring aromatization via retro-aldol reaction provided a flexible and efficient protocol for the synthesis of estrogens. To demonstrate the utility of the protocol, pharmaceutically attractive estrogens were synthesized from easily available 19-hydroxy-4-ene-3-keto steroids. (C) 2010 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000278497900021
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/23878
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
JING YU,XU CHENGGONG,Ding K,et al. Protecting group effect on the 1,2-dehydrogenation of 19-hydroxysteroids: a highly efficient protocol for the synthesis of estrogens[J]. Tetrahedron Lett.,2010,51(24):3242-3245.
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