资源化学研究进展
其他题名The Study of Resource Chemistry
田伟生; 史勇
2010
发表期刊化学进展
ISSN1005-281X
卷号22期号:4页码:537-556
其他摘要This review summarizes our research progress in resource chemistry, which related to the reaction of steroidal sapogenin ( natural resource compound) and fluoroalkanosulfonyl fluoride ( non-natural one) as well as their application in organic synthesis. The strategies and tactics of utilizing steroidal sapogenin in "atom economy" way are introduced in the first paragraph. For solving the environmental pollution and resource waste generated in the industrial utilization of steroidal sapogenin, our group developed new method that using 30% commercial H(2)O(2) instead of CrO(3) to oxidize pseudo-sapogenin, which made it possible to the 100% utilization of the steroidal sapogenin resource. Direct oxidization of steroidal sapogenin with the per-acid generated in situ starting from 30% commercial H(2)O(2) and acid can produce pregna-16,20-diol type compounds and 4R-methyl delta-valerolactone. Iodine induced abnormal Baeyer-Villiger rearrangement of sapogenin provided steroidal 16-hydroxyl-22-lactone and 3R-methyl gamma-butyrolactone. All of their degraded products have been applied in the synthesis of some steroidal medicine, insect hormone, perfume and natural product. The strategy of using intact skeleton of steroidal sapogenin to synthesize target molecule are also described. In second paragraph, the strategies and tactics of utilizing fluoroalkanosulfonyl fluoride are introduced. To make reaction symbiosis is a new ideal in order to enhance the utilization ratio of the resource compounds. We explore symbiotic reactions of vicinal diol epoxidation, alkene epoxidation and carbocation rearrangement with fluoroalkanosulfonyl fluoride hydrolysis based on this concept. The synthetic application of such reactions is also presented in this review.
部门归属中国科学院上海有机化学研究所
收录类别SCI
语种中文
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/23876
专题中科院天然产物有机化学重点实验室
通讯作者田伟生
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田伟生,史勇. 资源化学研究进展[J]. 化学进展,2010,22(4):537-556.
APA 田伟生,&史勇.(2010).资源化学研究进展.化学进展,22(4),537-556.
MLA 田伟生,et al."资源化学研究进展".化学进展 22.4(2010):537-556.
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