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学科主题: 天然产物有机化学
题名: 利用薯蓣皂甙元完整骨架形式合成1α, 25-二羟基维生素D3
其他题名: Formal synthesis of l alpha,25-dihydroxyvitamin D-3 by utilizing the intact skeleton of diosgenin
作者: 林静容 ; 王玉春 ; 许启海 ; 金荣华 ; 田伟生
通讯作者: 田伟生
刊名: 化学学报
发表日期: 2007-01-01
卷: 65, 期:16, 页:1685-1692
收录类别: SCI
部门归属: 上海师范大学; 上海有机化学研究所
英文摘要: (1S,3R)-Cholesta-5,7-diene-1,3,25-triol, a photochemical reaction precursor for the preparation of 1 alpha,25-dihydroxyvitamin D-3, was synthesized by utilizing the intact skeleton of diosgenin in 16 steps in 7.6% overall yield. The reductive E/F ring opening of 3-benzyloxy-diosgenin produced 3,16,26-cholesteratriol benzyl ether 5. The C-26 hydroxy group was shifted to C-25 through the elimination and hydroxylation after the selective removal of C-16 hydroxyl group in 5. The A/B structural unit of the target molecule was constructed by the functional transformation of the A/B ring of diosgenin. (1S,3R)-Cholesta-5,7-diene-1,3,25-triol can be converted into 1 alpha,25-dihydroxyvitamin D-3 according to the known photochemical reaction.
语种: 中文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/23856
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
林静容,王玉春,许启海,等. 利用薯蓣皂甙元完整骨架形式合成1α, 25-二羟基维生素D3[J]. 化学学报,2007,65(16):1685-1692.
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