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学科主题: 天然产物有机化学
题名: Novel Biodegradable Aliphatic Poly (butylene succinate-co-cyclic carbonate)s Bearing Functionalizable Carbonate Building Blocks: II. Enzymatic Biodegradation and in vitro Biocompatibility Assay
其他题名: 具有可功能化碳酸酯砌块的新型聚酯共聚碳酸酯:1、酶促降解与体外生物相容性评价
作者: Yang J(杨晶) ; Tian WS(田伟生) ; Li QB(李巧波) ; Li Y(李洋) ; Cao AM(曹阿民)
通讯作者: 曹阿民
刊名: Biomacromolecules
发表日期: 2004-01-01
卷: 5, 期:6, 页:2258-2268
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所高分子研究室
英文摘要: In a previous study, we have reported chemical synthesis of novel aliphatic poly(butylene succinate-co-cyclic carbonate) P(BS-co-CC)s bearing various functionalizable carbonate building blocks, and this work will continue to present our new studies on their enzymatic degradation and in vitro cell biocompatibility assay. First, enzymatic degradation of the novel P(BS-co-CC) film samples was investigated with two enzymes of lipase B Candida Antartic (Novozyme 435) and lipase Porcine Pancreas PPL, and it was revealed that copolymerizing linear poly(butylene succinate) PBS with a functionalizable carbonate building block could remarkably accelerate the enzymatic degradation of a synthesized product P(BS-co-CC), and its biodegradation behavior was found to strongly depend on the overall impacts of several important factors as the cyclic carbonate (CC) comonomer structure and molar content, molar mass, thermal characteristics, morphology, the enzyme-substrate specificity and so forth. Further, the biodegraded residual film samples and water-soluble enzymatic degradation products were allowed to be analyzed by means of proton nuclear magnetic resonance (1H NMR), gel permeation chromatograph (GPC), differential scanning calorimeter (DSC), attenuated total reflection FTIR (ATR-FTIR), scanning electron microscope (SEM) and liquid chromatograph-mass spectrometry (LC-MS). On the experimental evidences, an exo-type mechanism of enzymatic chain hydrolysis referentially occurring in the non-crystalline domains was suggested for the synthesized new P(BS-co-CC) film samples. With regard to their cell biocompatibilities, an assay with NIH 3T3 mouse fibroblast cell was conducted using the novel synthesized P(BS-co-CC) films as substrates with respect to the cell adhesion and proliferation, and these new biodegradable P(BS-co-CC) samples were found to exhibit as low cell toxicity as the PLLA control, particularly the two samples of poly(butylene succinate-co-18.7 mol% dimethyl trimethylene carbonate) P(BS-co-18.7 mol% DMTMC) and poly(butylene succinate-co-21.9 mol% 5-benzyloxy trimethylene carbonate) P(BS-co-21.9 mol% BTMC) were interestingly found to show much better cell biocompatibilities than the PLLA reference.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/23848
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Yang J,Tian WS,Li QB,et al. Novel Biodegradable Aliphatic Poly (butylene succinate-co-cyclic carbonate)s Bearing Functionalizable Carbonate Building Blocks: II. Enzymatic Biodegradation and in vitro Biocompatibility Assay[J]. Biomacromolecules,2004,5(6):2258-2268.
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