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学科主题: 生命有机化学
题名: Influences of the hydrophobicity of the heme-binding pocket on the properties and functions of cytochrome b5 mutants
其他题名: 血红素结合口袋的疏水性对细胞色素b5的突变体的性质和功能的影响
作者: Gan JH(甘建华) ; Wang YH(王韵华) ; Wu J(邬键) ; Huang ZX(黄仲贤) ; Xia ZX(夏宗芗)
通讯作者: 夏宗芗
刊名: Chin. J. Chem.
发表日期: 2003-01-01
卷: 21, 期:10, 页:1385-1389
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所生命有机国家开放实验室; 复旦大学
英文摘要: The mutation sites of the four mutants F35Y . P40V, V45E and V45Y of cytochrome b5 are located at the edge of the heme-binding pocket. The solvent accessible areas of the "pocket inte- rior" of the four mutants and the wild-type cytochrome b5 have been calculated based on their crystal structures at high resolu-tion. The change in the hydrophobicity of the heme-binding pocket resulting from the mutation can be quantitatively de. Scribed using the difference of the solvent accessible area of the "pocket interior" of each mutant from that of the wild-type cy-tochrome b5 . The inauences of the hydrophobicity of the heme- binding pocket on the protein stability and redox potential are discussed.
语种: 英语
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/23680
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Gan JH,Wang YH,Wu J,et al. Influences of the hydrophobicity of the heme-binding pocket on the properties and functions of cytochrome b5 mutants[J]. Chin. J. Chem.,2003,21(10):1385-1389.
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